Synaptic innervation to rat hippocampus by vasopressin-immuno-positive fibres from the hypothalamic supraoptic and paraventricular nuclei

Zhang, Limei; Hernández, Vito S.

doi:10.1016/j.neuroscience.2012.10.010

Cited by 91 publications

(151 citation statements)

References 55 publications

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“…Extrahippocampal inputs to CA2 include those from vasopressinergic neurons in the PVN 10,11 and from the median raphe, as well as reciprocal connectivity to and from the SuM 36,37,43 , medial septum and the diagonal bands of Broca 10 . In rats, SuM neurons appear to form synapses onto pyramidal neurons that are asymmetric in their appearance (that is, they are likely to be excitatory) 33 , and they provide the major contribution of the substance P-containing synaptic terminals to the hippocampus 36,37,43 .…”

Section: Identifying Area Ca2mentioning

confidence: 99%

“…Inputs from the SuM and PVN heavily innervate CA2 and distal CA3a, and appear to delineate the molecularly defined CA2 (REF. 11) (FIG. 2).…”

Section: Identifying Area Ca2mentioning

confidence: 99%

“…In addition, it has been shown that the presence of heavy axonal input from the supramammillary nucleus (SuM) and the paraventricular nucleus (PVN) of the hypothalamus may also be helpful when identifying the CA3–CA2 boundary, as the bulk of axonal projections from these regions terminate precisely at the site of molecular markers that delineate CA2 pyramidal neurons in rodents 9–11 . Thus, expression of genes enriched in the CA2 region, together with the distribution of SuM and PVN inputs to the hippocampus, may suffice to define CA2 in many species, rather than relying on Lorente de Nó’s definition that is dependent on the presence or absence of mossy fibre input 12 (FIG.…”

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confidence: 99%

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Rediscovering area CA2: unique properties and functions

2016

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Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.

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Section: Identifying Area Ca2mentioning

confidence: 99%

“…Inputs from the SuM and PVN heavily innervate CA2 and distal CA3a, and appear to delineate the molecularly defined CA2 (REF. 11) (FIG. 2).…”

Section: Identifying Area Ca2mentioning

confidence: 99%

mentioning

confidence: 99%

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Rediscovering area CA2: unique properties and functions

2016

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“…By decreasing threshold for potentiation and by rendering neurons more sensitive to external stimulation, OT and VP permit social recognition and concomitant expression of appropriate social aggression [37]. Although the endogenous agonist might originate from described projections from the MeA and BNST VP neurons, recent findings indicate projections from the PVN both in mice and rats as an important source [38,39].…”

Section: Hippocampusmentioning

confidence: 99%

Neuromodulation by oxytocin and vasopressin in the central nervous system as a basis for their rapid behavioral effects

Stoop

2014

Current Opinion in Neurobiology

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The last several years have seen an increasing number of studies that describe effects of oxytocin and vasopressin on the behavior of animals or humans. Studies in humans have reported behavioral changes and, through fMRI, effects on brain function. These studies are paralleled by a large number of reports, mostly in rodents, that have also demonstrated neuromodulatory effects by oxytocin and vasopressin at the circuit level in specific brain regions. It is the scope of this review to give a summary of the most recent neuromodulatory findings in rodents with the aim of providing a potential neurophysiological basis for their behavioral effects. At the same time, these findings may point to promising areas for further translational research towards human applications.

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“…However, they cannot readily penetrate the blood-brain barrier. Therefore, their cen-tral actions are probably exerted as neuropeptides synthesized in the paraventricular hypothalamic nucleus and possibly other brain regions, from which oxytocin-and vasopressincontaining terminals reach a variety of brain areas [322] including the hippocampus [323,324]. Both oxytocin and vasopressin mRNA expressions are elevated in the paraventricular hypothalamic nucleus during seizures [325].…”

Section: Oxytocin and Vasopressinmentioning

confidence: 99%

Receptors of Peptides as Therapeutic Targets in Epilepsy Research

Dobolyi¹,

Kékesi²,

Juhász³

et al. 2014

CMC

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Neuropeptides are signaling molecules participating in the modulation of synaptic transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of which requires profound excitation. Only in the extracellular space, neuropeptides act on G-protein coupled receptors to exert a relatively slow action both pre-and postsynaptically. Consequently, neuropeptide modulators are ideal candidates to influence epileptic tissue overexcited during seizures. Indeed, a number of neuropeptides have been implicated in epilepsy and many of them are considered to have endogenous neuroprotective actions. Neuropeptides, present in the hippocampus, the most frequent focus of seizures in temporal lobe epilepsy, received the largest attention as potential anti-epileptic substances. Hippocampal neuropeptides, somatostatin, neuropeptide Y, galanin, dynorphin, enkephalin, substance P, cholecystokinin, vasoactive intestinal polypeptide, and some neuropeptides, which are also hormones such as ghrelin, angiotensins, corticotropin-releasing hormone, adrenocorticotropin, thyrotropin-releasing hormone, oxytocin and vasopressin involved in epilepsy are discussed in the review article. Oral application of neuropeptides as drugs is typically not efficient because of low bioavailability: rapid degradation and insufficient penetration through the blood-brain barrier. Recent progress in the development of non-peptide agonists and antagonists of neuropeptide receptors as well as gene therapeutic approaches leading to the local production of neuropeptides within the central nervous system will also be discussed.

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Synaptic innervation to rat hippocampus by vasopressin-immuno-positive fibres from the hypothalamic supraoptic and paraventricular nuclei

Cited by 91 publications

References 55 publications

Rediscovering area CA2: unique properties and functions

Rediscovering area CA2: unique properties and functions

Neuromodulation by oxytocin and vasopressin in the central nervous system as a basis for their rapid behavioral effects

Receptors of Peptides as Therapeutic Targets in Epilepsy Research

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