2020
DOI: 10.3389/fncel.2020.00204
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Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?

Abstract: Inhibitory neurons play a fundamental role in the normal operation of neuronal networks. Diverse types of inhibitory neurons serve vital functions in cortical networks, such as balancing excitation and taming excessive activity, organizing neuronal activity in spatial and temporal patterns, and shaping response selectivity. Serving these, and a multitude of other functions effectively requires fine-tuning of inhibition, mediated by synaptic plasticity. Plasticity of inhibitory systems can be mediated by change… Show more

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Cited by 25 publications
(25 citation statements)
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References 147 publications
(482 reference statements)
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“…Several identities of this circuit are consistent with our data. Sparsening could be mediated by a class of local interneurons, whose inputs from local pyramidal cells tuned to taskinformative stimuli are strengthened after learning (29,30). Alternatively, it could be mediated by feedback from more distal cortical regions or neuromodulators, which target local inhibitory circuits to cause retinotopically-aligned suppression.…”
Section: Discussionmentioning
confidence: 99%
“…Several identities of this circuit are consistent with our data. Sparsening could be mediated by a class of local interneurons, whose inputs from local pyramidal cells tuned to taskinformative stimuli are strengthened after learning (29,30). Alternatively, it could be mediated by feedback from more distal cortical regions or neuromodulators, which target local inhibitory circuits to cause retinotopically-aligned suppression.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental results confirming this prediction offer broader evidence in support of the proposed homeostatic role of heterosynaptic plasticity during on-going associative learning (Oja 1982;MIller and MacKay 1994;von der Malsburg 1973;Miller 1996;Watt et. al., 2010;Zenke and Gerstner 2017;Bannon et. al., 2020).…”
Section: Discussionmentioning
confidence: 99%
“…This new relationship can further help to understand a range of observations. Since this cooperation originates from excitatory neurons' desire to monopolize a certain input pattern, it is not hard to understand why the strongest lateral inhibition will occur among neurons that fire together [84], why the inhibition will dynamically increase with excitation [85,86], and why the distribution of inhibition is found to be precisely matched with that of excitation [87,88,89]. All these facts follow the logic that inhibitory neurons are recruited for the competition among excitatory neurons.…”
Section: Inhibitionmentioning
confidence: 91%