Synbiotic supplementation containing <i>Bifidobacterium infantis</i> and xylooligosaccharides alleviates dextran sulfate sodium-induced ulcerative colitis

Sheng, Kangliang; He, Shiman; Sun, Ming; Zhang, Guanghui; Kong, Xiaowei; Wang, Jingmin; Wang, Yongzhong

doi:10.1039/d0fo00518e

Cited by 70 publications

(55 citation statements)

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“…Numerous studies have highlighted the capacity of specific bacterial phylotypes in triggering beneficial immunological responses and reducing the severity of inflammatory diseases. This is the case of Bifidobacteria and Lactobacilli species, which attenuate intestinal inflammation and metabolic disturbances in ulcerative colitis ( 50 , 51 ) and obesity ( 52 , 53 ). For instance, certain probiotic strains, such as L. plantarum WCFS1, improve inflammation by lowering the levels of plasma proinflammatory cytokines ( 51 ).…”

Section: The Gut Microbiota and Its Involvement In Host Healthmentioning

confidence: 99%

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

et al. 2021

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The genome of gut microbes encodes a collection of enzymes whose metabolic functions contribute to the bioavailability and bioactivity of unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, and other omics have expanded the understanding of the different modes of actions by which (poly)phenols modulate the microbiome conferring health benefits to the host. Progress have been made to identify direct prebiotic effects of (poly)phenols; albeit up to date, these compounds are not recognized as prebiotics sensu stricto. Interestingly, certain probiotics strains have an enzymatic repertoire, such as tannase, α-L-rhamnosidase, and phenolic acid reductase, involved in the transformation of different (poly)phenols into bioactive phenolic metabolites. In vivo studies have demonstrated that these (poly)phenol-transforming bacteria thrive when provided with phenolic substrates. However, other taxonomically distinct gut symbionts of which a phenolic-metabolizing activity has not been demonstrated are still significantly promoted by (poly)phenols. This is the case of Akkermansia muciniphila, a so-called antiobesity bacterium, which responds positively to (poly)phenols and may be partially responsible for the health benefits formerly attributed to these molecules. We surmise that (poly)phenols broad antimicrobial action free ecological niches occupied by competing bacteria, thereby allowing the bloom of beneficial gut bacteria. This review explores the capacity of (poly)phenols to promote beneficial gut bacteria through their direct and collaborative bacterial utilization and their inhibitory action on potential pathogenic species. We propose the term duplibiotic, to describe an unabsorbed substrate modulating the gut microbiota by both antimicrobial and prebiotic modes of action. (Poly)phenol duplibiotic effect could participate in blunting metabolic disturbance and gut dysbiosis, positioning these compounds as dietary strategies with therapeutic potential.

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Section: The Gut Microbiota and Its Involvement In Host Healthmentioning

confidence: 99%

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

et al. 2021

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“…Mice in the SePSP group received oral administration of 200 mg kg −1 SePSP (0.2 mL) by gavage for 21 days, while the other groups were orally administered 0.2 mL of distilled water by gavage. From day 14, both the DSS group and the SePSP group received oral administration of 3% DSS in drinking water, continuously for 7 days to induce UC 33 . Occult and gross fecal bleeding, stool consistency, and weight loss were recorded every day for all mice in each group.…”

Section: Methodsmentioning

confidence: 99%

“…A malondialdehyde (MDA) assay kit (A003‐1, Nanjing Jiancheng Bioengineering Institute, Nanjing, China) was used to determine serum MDA concentration, according to a standard thiobarbituric acid (TBA) method 33 . According to the manufacturer's instructions, 100 μL of serum from each mouse was mixed with the appropriate reaction reagents and incubated in a water bath at 95 °C for 40 min.…”

Section: Methodsmentioning

confidence: 99%

Purification and antioxidant and anti‐Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola

et al. 2020

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BACKGROUNDSanghuang mushrooms are medicinal fungi widely used in eastern Asia. In this study, the antioxidant and anti‐inflammatory activity of a novel extracellular polysaccharopeptide, sanghuang extracellular polysaccharopeptide (SePSP) was investigated. The SePSP was purified from the submerged fermentation broth of a sanghuang mycelium, Sanghuangporus lonicericola strain CBS17, which was isolated from a wild sanghuang fruiting body.RESULTSThe SePSP was extracted using an ethanol precipitation procedure, followed by diethylaminoethanol (DEAE) anion‐exchange and size‐exclusion chromatography. The mass ratio of the polysaccharide and peptide components in the purified SePSP was approximately 4.87:1. By determining its free radical scavenging abilities using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), the hydroxyl free radical, and the superoxide anion free radical, as well as its total reducing power, SePSP was shown to have strong concentration‐dependent antioxidant activity in vitro. Further, SePSP effectively alleviated dextran sodium sulfate (DSS)‐induced ulcerative colitis (UC) in mice. Administration of 200 mg kg−1 SePSP by gavage for 7 days prevented body weight loss; significantly reduced the mRNA levels of proinflammatory cytokines, including TNF‐α and IL‐1β; increased mRNA level of the anti‐inflammatory cytokine IL‐10 in the colon, and decreased the malondialdehyde concentration from 6.42 to 4.82 μmol L−1 in the blood in UC mice.CONCLUSIONThe SePSP had strong concentration‐dependent antioxidant activity in vitro and effectively alleviated DSS‐induced UC in mice. The in vivo therapeutic efficacy in DSS‐induced UC may be mediated by modulating the expression of inflammatory cytokines and inhibiting oxidative stress. The findings provide a scientific rationale for the use of bioactive nutraceuticals from sanghuang mushrooms to develop functional foods for the prevention and treatment of UC. © 2020 Society of Chemical Industry

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“…Treatment with synbiotic XOS and Bifidobacterium infantis downregulated the proinflammatory cytokines (TNF-α and IL-1β) and upregulated the anti-inflammatory cytokines (IL-10) in the colon cells of a dextran sodium sulfate-induced mouse. XOS supplementation significantly enhanced the expression of different junction proteins, including claudin-1 tight junction (TJ), zonula occludens-1 (ZO-1), and occluding junction in the colon tissue ( 75 ). Apart from XOS, MOS have also been found to alleviate IBD symptoms.…”

Section: Role Of Hdos In Disease Alleviationmentioning

confidence: 99%

Hemicellulose-Derived Oligosaccharides: Emerging Prebiotics in Disease Alleviation

Jana

Kango²,

Pletschke³

2021

Front. Nutr.

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The gut microbiota in the human body is an important component that plays a pivotal role in the ability of the host to prevent diseases and recover from these diseases. If the human microbiome changes for any reason, it affects the overall functioning of the host. Healthy and vigorous gut microbiota require dietary fiber supplementation. Recently, oligosaccharides have been found to play a significant role in the modulation of microbiota. Several such oligosaccharides, i.e., xylooligosaccharides (XOS), mannooligosaccharides (MOS), and arabino-xylooligosaccharides (AXOS), are derived from hemicellulosic macromolecules such as xylan, mannan, and arabino-xylan, respectively. These oligosaccharides serve as substrates for the probiotic production of health-promoting substances (short-chain fatty acids, branched chain amino acids etc.), which confer a variety of health benefits, including the prevention of some dreaded diseases. Among hemicellulose-derived oligosaccharides (HDOs), XOS have been largely explored, whereas, studies on MOS and AXOS are currently underway. HDOs, upon ingestion, help reduce morbidities by lowering populations of harmful or pathogenic bacteria. The ATP-binding cassette (ABC) transporters are mainly utilized for the uptake of oligosaccharides in probiotics. Butyrate generated by the selective fermentation of oligosaccharides, along with other short-chain fatty acids, reduces gut inflammation. Overall, oligosaccharides derived from hemicelluloses show a similar potential as conventional prebiotics and can be supplemented as functional foods. This review summarizes the role of HDOs in the alleviation of autoimmune diseases (inflammatory bowel disease, Crohn's disease), diabetes, urinary tract infection, cardiovascular diseases, and antimicrobial resistance (AMR) through the modulation of the gut microbiota. The mechanism of oligosaccharide utilization and disease mitigation is also explained.

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Synbiotic supplementation containing Bifidobacterium infantis and xylooligosaccharides alleviates dextran sulfate sodium-induced ulcerative colitis

Abstract: Synbiotics (Bifidobacterium infantis + xylooligosaccharides) had the strongest efficacy on colitis through inhibiting inflammation and oxidative stress and protecting epithelial integrity.

Cited by 70 publications

References 40 publications

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

Purification and antioxidant and anti‐Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola

Hemicellulose-Derived Oligosaccharides: Emerging Prebiotics in Disease Alleviation

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