Synchronization to auditory and visual beats in Parkinson's disease

Wu, Qian; Zhou, Yuntao; Li, Minying; Mei, Xiaolin; Wu, Youliang; Fu, Wenbin; Wu, Xi

doi:10.1016/j.parkreldis.2020.08.029

Cited by 3 publications

(1 citation statement)

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“…A previous study ( Magalhães et al, 2018 ), consisting of far smaller participant cohorts, have concentrated on in-person visual perception tasks alone. Another study found movement synchronization to visual but not auditory stimuli was impaired by PD ( Wu et al, 2020 ), suggesting a visuomotor timing deficiency in patients. Since the auditory system is known to have higher resolution in temporal perception ( Rammsayer et al, 2015 ) and engage different circuits in the somatosensory system ( Comstock et al, 2018 ), examining both auditory and visual time perception is crucial to better understand timing impairments in PD.…”

Section: Introductionmentioning

confidence: 99%

Parkinson’s disease deficits in time perception to auditory as well as visual stimuli – A large online study

Patel²,

Bredemeyer³

et al. 2022

Front. Neurosci.

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Cognitive deficits are common in Parkinson’s disease (PD) and range from mild cognitive impairment to dementia, often dramatically reducing quality of life. Physiological models have shown that attention and memory are predicated on the brain’s ability to process time. Perception has been shown to be increased or decreased by activation or deactivation of dopaminergic neurons respectively. Here we investigate differences in time perception between patients with PD and healthy controls. We have measured differences in sub-second- and second-time intervals. Sensitivity and error in perception as well as the response times are calculated. Additionally, we investigated intra-individual response variability and the effect of participant devices on both reaction time and sensitivity. Patients with PD have impaired sensitivity in discriminating between durations of both visual and auditory stimuli compared to healthy controls. Though initially designed as an in-person study, because of the pandemic the experiment was adapted into an online study. This adaptation provided a unique opportunity to enroll a larger number of international participants and use this study to evaluate the feasibility of future virtual studies focused on cognitive impairment. To our knowledge this is the only time perception study, focusing on PD, which measures the differences in perception using both auditory and visual stimuli. The cohort involved is the largest to date, comprising over 800 participants.

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