Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life

Saha, Hinglaj; Ghosh, Dipak; Biswas, Somak Kumar; Mishra, Prafulla Kumar; Kaushik, Sushmita; Chatterjee, Uttara

doi:10.4103/jiaps.jiaps_42_18

Cited by 3 publications

(2 citation statements)

References 30 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kidney failure, early after bilateral Wilms tumor treatment varies from 0% to 54% in available reports [ 25 , 28 , 30 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 43 , 44 , 46 , 49 , 50 , 51 , 52 , 54 , 55 , 59 ]. Unfortunately, from the larger series, only Hamilton et al (12%) and Montgomery et al (5%) presented data on ESKD [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

Peer

Hol

Steeg

et al. 2021

JCM

View full text Add to dashboard Cite

Survival of unilateral Wilms tumors (WTs) is exceeding 90%, whereas bilateral WTs have an inferior outcome. We evaluated all Dutch patients with bilateral kidney tumors, treated in the first five years of national centralization and reviewed relevant literature. We identified 24 patients in our center (2015–2020), 23 patients had WT/nephroblastomatosis and one renal cell carcinoma. Patients were treated according to SIOP-RTSG protocols. Chemotherapy response was observed in 26/34 WTs. Nephroblastomatosis lesions were stable (n = 7) or showed response (n = 18). Nephron-sparing surgery was performed in 11/22 patients undergoing surgery (n = 2 kidneys positive margins). Local stage in 20 patients with ≥1 WT revealed stage I (n = 7), II (n = 4) and III (n = 9). Histology was intermediate risk in 15 patients and high risk in 5. Three patients developed a WT in a treated nephroblastomatosis lesion. Two of 24 patients died following toxicity and renal failure, i.e., respectively dialysis-related invasive fungal infection and septic shock. Genetic predisposition was confirmed in 18/24 patients. Our literature review revealed that knowledge is scarce on bilateral renal tumor patients with metastases and that radiotherapy seems important for local stage III patients. Bilateral renal tumors are a therapeutic challenge. We describe management and outcome in a national expert center and summarized available literature, serving as baseline for further improvement of care.

show abstract

Section: Discussionmentioning

confidence: 99%

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

Peer

Hol

Steeg

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…But for patients with recurrence or more aggressive disease, combination chemotherapy is usually administered. 27 , 28 For WT patients with poor prognosis, considering the side effects of chemotherapy, immune checkpoint inhibitors may be a feasible selection. The study of plasma ePD-L1 in WT patients is helpful for the choice of immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

EV PD-L1 Contributes to Immunosuppressive CD8⁺ T Cells in Peripheral Blood of Pediatric Wilms Tumor

Zhang

Liu

Hou

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

Wilms tumor (WT) is the most common renal cancer and the most prevalent abdominal cancer in children. Children with recurrent or progressive forms of WT could benefit from novel immune-targeted approaches. While the immune status of these patients, especially the immunosuppression of peripheral T cells, was rarely reported. The present study enrolled a consecutive series of 14 Chinese WT children and 14 age- and gender-matched healthy controls. We demonstrated that plasma extracellular vesicular (EV) PD-L1 levels significantly increased in WT patients than in healthy controls. EV PD-L1 significantly inhibited the activation of human CD8+ T cells by down-regulating the cell surface CD69 expression and the intracellular IFNγ and TNFα production in vitro. In peripheral CD8+ T cells of WT patients, the intracellular IFNγ and TNFα production significantly decreased than healthy controls. The level of plasma EV PD-L1 significantly correlated with the intracellular TNFα production in peripheral CD8+ T cells of WT patients. In conclusion, the significantly increased plasma EV PD-L1 in WT patients contributed to the immunosuppression of peripheral CD8+ T cells. Monitoring the level of plasma EV PD-L1 will be helpful for the selection of immune-targeted therapies for WT patients.

show abstract

Comprehensive analysis of competing endogenous RNA network in Wilms tumor based on the TARGET database

Guan

Tian

2020

Transl Androl Urol

View full text Add to dashboard Cite

Background: Wilms tumor (WT) was the most common malignant tumor of urinary system in children.With the advances in gene sequencing, research of molecular mechanism of WT tumor was gradually increasing. However, few studies have explored the influence of competing endogenous RNA (ceRNA) in WT. Accordingly, we aimed to explore the mechanisms of ceRNA co-expression network in WT.Methods: A total of 6 non-tumor controls and 127 WT patients' RNA-seq data combined with clinical data was acquired from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Differentially expressed lncRNA, miRNA and mRNA between WT tissues and normal tissues were analyzed using "edgeR" package in R software. Weighted gene co-expression network analysis (WGCNA) was utilized to construct the ceRNA co-expression network while Molecular Complex Detection (MCODE) algorithm was used to extract the pivotal sub-network. Function annotation of mRNA was performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Survival analysis was then conducted based on long-rank test and Kaplan-Meier curves using the survival package.Results: By applying the "edgeR" package in R, the transcriptome expression data of 127 WT tissues with 6 normal tissues were normalized. Moreover, 146 DElncRNAs, 62 DEmiRNAs, 287 DEmRNAs of them were involved in ceRNA network after applying WGCNA. According to MCODE, we identified that the interactions between LINC002253 (lncRNA) and TRIM71 (mRNA) was mediated by hsa-mir-301a and hsamir-301b (miRNA). Furthermore, we detected 13 DElncRNAs which were significantly associated with the progression of WT. Conclusions:We used WGCNA method to construct the WT ceRNA network for the first time.TRIM71 was identified to be the most closely related genes involved in hub sub-network by MCDOE, suggesting it might act as a new drug target and prognostic factor based on our comprehensive results.

show abstract

Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life

Cited by 3 publications

References 30 publications

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

EV PD-L1 Contributes to Immunosuppressive CD8⁺ T Cells in Peripheral Blood of Pediatric Wilms Tumor

Comprehensive analysis of competing endogenous RNA network in Wilms tumor based on the TARGET database

Contact Info

Product

Resources

About

Synchronous bilateral wilms tumor: Five-year single-center experience with assessment of quality of life

Cited by 3 publications

References 30 publications

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

Bilateral Renal Tumors in Children: The First 5 Years’ Experience of National Centralization in The Netherlands and a Narrative Review of the Literature

EV PD-L1 Contributes to Immunosuppressive CD8+ T Cells in Peripheral Blood of Pediatric Wilms Tumor

Comprehensive analysis of competing endogenous RNA network in Wilms tumor based on the TARGET database

Contact Info

Product

Resources

About

EV PD-L1 Contributes to Immunosuppressive CD8⁺ T Cells in Peripheral Blood of Pediatric Wilms Tumor