Synchronous cerebral arteriovenous malformation and lung adenocarcinoma carcinoma brain metastases: A case study and literature review

Caranfa, Jonathan T.; Baldwin, Michael; Rutter, C.E.; Bulsara, Ketan R.

doi:10.1016/j.neuchi.2018.07.003

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…The etiology of the AVM remains unclear; however, both genetic and angiogenic stimulations are thought to play roles in the development of pathogenesis (26). On the other hand, angiogenic factors are thought to be the major factors in AVM development (6,14,15,21,28). Therefore, in the present study, we aimed to investigate the effect of cerebral artery occlusion on sVEGFR1, sVEGFR2, and VEGF levels as well as angiogenesis in rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of cerebral ischemia on levels of vascular endothelial growth factor (vegf) and its soluble receptors: a possible link to angiogenesis in arteriovenous malformations.

Bayraktar

Turkoz²,

Turkoz³

et al. 2021

Turkish Neurosurgery

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AIM:To investigate the levels of vascular endothelial growth factor (VEGF) in the brain, and its soluble forms, namely sVEGFR1 and sVEGFR2, levels in the plasma of rats after cerebral ischemia.MATERIAL and METHODS: Rats were divided into three groups as follows: Group 1: Sham-operated group, Group 2: Complete occlusion of the right carotid artery, Group 3: Complete occlusion of the right carotid artery and temporary occlusion of the left carotid artery for 10 min. Blood samples were collected on days 0 and 10 prior to the sacrification to measure the sVEGFR1 and sVEGFR2 levels. On day 10, animals were sacrificed, and brain tissue was collected to analyze VEGF expression. RESULTS:Postoperative sVEGFR1 levels reduced significantly in Group 3, while it remained stable in other groups. sVEGFR2 levels did not change in any group. Although VEGF staining scores in the groups that underwent ischemia procedures increased compared to group 1, no significant differences were observed.CONCLUSION: Decreased levels of sVEGFR1 can be a mechanism contributing to angiogenesis in arteriovenous malformations by increasing the levels of VEGF available to bind membrane-bound VEGFRs.

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Section: Discussionmentioning

confidence: 99%

Effects of cerebral ischemia on levels of vascular endothelial growth factor (vegf) and its soluble receptors: a possible link to angiogenesis in arteriovenous malformations.

Bayraktar

Turkoz²,

Turkoz³

et al. 2021

Turkish Neurosurgery

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“…Більшість дослідників є прихильниками концепції про багатофакторну етіологію (генетичні мутації, ангіогенна стимуляція (фізіологічний процес утворення нових судин із існуючих). Одні автори вказують на внутрішньоутробний розвиток АВМ, іншіна ангіопатичну реакцію після ішемічної або геморагічної події у мозку, як основний чинник розвитку цієї патології [2][3][4][5].…”

Section: огляди літературиunclassified

Endovascular embolization of cerebral arteriovenous malformations

Shchehlov¹,

Svyrydiuk²,

Chebanyuk³

et al. 2022

Ukr. ìnterv. nejroradìol. hìr.

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Endovascular embolization is a critical component in the treatment of cerebral arteriovenous malformations. It can be used as an independent treatment modality or as an adjunct to microurgery or radiosurgery. The published literature in the PubMed database until September 2021 was reviewed with reference to the results of cerebral arteriovenous malformations embolization using liquid embolic agents. More scientific data reporting about total embolization of the cerebral arteriovenous malformations with a final cure. Although complications and mortality after arteriovenous malformations embolization have decreased significantly, but they still exist, and decisions about it usage should be weighed against its benefits during the planning phase. Treatment of arteriovenous malformations of the brain requires a multidisciplinary approach involving vascular neurosurgeons, endovascular interventionists and radiation oncologists, with a deep understanding of the natural course and combination of risks of multimodal treatment. Only such approach can increase the likelihood of a positive outcome of the cerebral arteriovenous malformations treatment.

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Features of treatment of patients with combination of aneurysm or arteriovenous malformations and intracranial tumors: clinical cases and a literature review

Grebenev¹,

Chernov²,

Konovalov³

et al. 2023

Bulletin of Neurology, Psychiatry and Neurosurgery

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The combination of vascular pathology of the brain and neurooncological disease is quite rare in neurosurgical practice: the combination with aneurysms is in the range of 0.7–5.4 %, while the true incidence of combinations with arteriovenous malformations (AVMs) is unknown due to the extremely rare occurrence. Such combinations present several problems, such as the early preoperative diagnosis of vascular pathology, as well as the tactics of treating such patients. There is no consensus in the literature regrading the treatment tactics for such patients.The aim of this work is to present modern approaches to the treatment of patients with a combination of vascular and oncological intracranial pathologies, as well as our own clinical cases: combinations of chordoma, tumor of the pyramid of the temporal bone,and aneurysm, meningioma of the base of the anterior cranial fossa (ACF) and aneurysm, meningioma of the base of the ACF an AVM, and glioblastoma and AVM.

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Synchronous cerebral arteriovenous malformation and lung adenocarcinoma carcinoma brain metastases: A case study and literature review

Cited by 5 publications

References 14 publications

Effects of cerebral ischemia on levels of vascular endothelial growth factor (vegf) and its soluble receptors: a possible link to angiogenesis in arteriovenous malformations.

Effects of cerebral ischemia on levels of vascular endothelial growth factor (vegf) and its soluble receptors: a possible link to angiogenesis in arteriovenous malformations.

Endovascular embolization of cerebral arteriovenous malformations

Features of treatment of patients with combination of aneurysm or arteriovenous malformations and intracranial tumors: clinical cases and a literature review

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