Synchronous Chemoradiation Nanovesicles by X‐Ray Triggered Cascade of Drug Release

Zhou, Zijian; Chan, Alexander; Wang, Zhantong; Huang, Xiaolin; Yu, Guocan; Jacobson, Orit; Wang, Sheng; Liu, Yijing; Shan, Lingling; Dai, Yunlu; Shen, Zheyu; Lin, Lisen; Chen, Wei; Chen, Xiaoyuan

doi:10.1002/anie.201802351

Cited by 64 publications

(40 citation statements)

References 45 publications

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“…Recently, our group introduced X‐ray‐activated drug release with DOX‐loaded Au nanovehicles . The X‐ray‐responsive Au nanovehicles were composed of X‐ray‐sensitive linoleic acid hydroperoxide (LAHP) molecules and oxidation‐activated poly(propylene sulfide)‐poly(ethylene glycol) (PPS‐PEG) polymer.…”

Section: X‐ray‐excited Synchronous/synergistic Therapymentioning

confidence: 99%

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Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

et al. 2019

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treat cancer patients; however, it can cause severe systemic toxicity and immunesystem depression due to its nonspecific nature. [2][3][4] As a noninvasive therapeutic modality, radiotherapy (RT) with assistance from image guidance/positioning can be used to deliver X/γ-ray radiation to tumors. [5][6][7][8] This enables radiation oncologists to target malignant tissues for precise cancer therapy [9][10][11] while minimizing radiation dose delivered to surrounding normal tissues. However, RT efficacy can be attenuated by factors like salient hypoxia found in solid tumors. [12][13][14][15] Moreover, some cancer subtypes and cancer stem cells exhibit high resistance to X-ray radiation. [16] Consequently, the development of radiosensitizers that can sensitize hypoxic or radio-resistant tumors to X-ray radiation [17][18][19][20] has become an area of intense research.The emerging radiosensitizers can be classified into three groups: gasotransmitters (e.g., O 2 , NO, H 2 S, etc.), [21][22][23][24][25] anticancer drugs (e.g., paclitaxel (PTX), docetaxel (Dtxl), topotecan (TPT), etc.), [26][27][28] and high-Z elements (e.g., Au, Ba, Bi, Pt, W, etc.). [29][30][31][32][33][34][35] The gasotransmitters can mimic the radiosensitizing effect of oxygen and downregulate hypoxia-inducible factor-1 alpha (HIF-1α) expression, [23] while anticancer drugs can induce cancer cells to enter the G2/M phase which is the most radiation-sensitive cell-cycle phase. [36] High-Z elements are known for scattering one X-ray beam into several beams to concentrate more radiation on tumors for aggravated radiation damage. [37,38] This radiation dose-amplification effect is based on the Compton scattering mechanism. [39] All of these radiosensitizers are usually loaded or engineered into nanocarriers for tumor-specific delivery or by passive tumor accumulation via the enhanced permeability and retention (EPR) effect. [40] Heretofore, a great number of nanomaterials have been synthesized to pave the way for high-performance radiosensitization for RT enhancement. [41][42][43][44] Despite the appreciable progress achieved in X-ray radiation sensitization/enhancement, RT as a monotherapy generally fails to eliminate the whole tumor as cancer cells can undergo DNA-repair and regrowth. [45,46] As such, current research is gradually shifting from RT monotherapy to X-rayexcited multimodal therapy. This means that two or more therapeutic modalities are simultaneously activated by X-ray to yield synchronous/synergistic anticancer effects. [47][48][49] For example, it has been shown that high-energy X-ray irradiation can triggerThe advancements in nanotechnology have created multifunctional nanomaterials aimed at enhancing diagnostic accuracy and treatment efficacy for cancer. However, the ability to target deep-seated tumors remains one of the most critical challenges for certain nanomedicine applications. To this end, X-ray-excited theranostic techniques provide a means of overcoming the limits of light penetration and tissue attenuation. Herein, a comprehe...

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Section: X‐ray‐excited Synchronous/synergistic Therapymentioning

confidence: 99%

Section: X‐ray‐excited Synchronous/synergistic Therapymentioning

confidence: 99%

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

et al. 2019

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“…Such precise synchronization of multi‐model therapies has become the tendency in anti‐tumor and anti‐infection fields. Our group and other groups have tried to design some nano‐drug delivery systems (NDDSs) to achieve this goal. We believe that our findings in this work not only extend the knowledge that Pt NPs can be used as a new class of antimicrobial agent, but may also broaden the application of precise synchronization of multi‐model therapies.…”

mentioning

confidence: 99%

Photoactivated Trifunctional Platinum Nanobiotics for Precise Synergism of Multiple Antibacterial Modes

Deng

Zhao

Shi

et al. 2019

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Staphylococcus aureus, where bacterial viability and colony-forming units are significantly reduced. Moreover, similar results are observed in mice subcutaneous abscess models. Significantly, after NIR treatment, dvPtNP exhibits a more robust bacteria-killing efficiency than other PtNP groups, owing to its integration of dramatic damage to the bacterial membrane and DNA, and alteration to ATP and ROS metabolism. This study broadens the avenues for designing and synthesizing antibacterial materials with higher efficiency.

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“…A somewhat similar approach was followed by Zhou et al. who developed polymeric nanovesicles (80–90 nm) composed of ROS responsive poly(propylene sulfide)‐poly(ethylene glycol) (PPS‐PEG) amphiphilic polymers and hydrophobic AuNPs tethered with X‐ray labile linoleic acid hydroperoxide (LAHP) molecules . DOX was encapsulated in the vesicle lumen serving as a model drug.…”

Section: Radiation Triggered Releasementioning

confidence: 99%

Section: Radiation Triggered Releasementioning

confidence: 99%

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

Denkova

Liu

Men

et al. 2020

Advanced Therapeutics

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Next to surgery, radiotherapy and chemotherapy are the two most commonly applied treatments against cancer. These therapies are often combined, but the therapeutic outcome is still limited. Nanocarriers may be the solution to many of the issues encountered when combining these therapies. In this review, the role of nanocarriers in combined radiotherapy and chemical cancer treatment is discussed, divided into four distinct strategy classes. For each strategy, examples of the literature are given to come eventually to conclusion on the possible translation to the clinic.

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Synchronous Chemoradiation Nanovesicles by X‐Ray Triggered Cascade of Drug Release

Cited by 64 publications

References 45 publications

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Photoactivated Trifunctional Platinum Nanobiotics for Precise Synergism of Multiple Antibacterial Modes

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

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