Synchronous ileal carcinoid and primary colonic neoplasms: a case report

Abstract

Primary colonic tumours with synchronous ileal carcinoid tumours are rare in occurrence and are mainly found incidentally on autopsies or pathological examination of resected surgical specimens. This article describes a case of adenomatous colonic polyps, adenocarcinoma of sigmoid colon and concurrent malignant carcinoid tumour of ileocaecal junction, detected on colonoscopic examination. The radiological staging investigations revealed no distant spread of disease. The patient was effectively treated with subtotal colectomy, resection of terminal ileum, excision of locoregional lymph nodes and the bowel continuity was restored with stapled ileo-rectal anastomosis. This article is as an example of concomitant presence of two types of malignant tumours, effectively managed surgically.

Multiple peripheral typical carcinoid tumors of the lung: associated with sclerosing hemangiomas

“…Patients in this study had a past history of various malignancies such as breast cancer, endometrial adenocarcinoma, colon adenocarcinoma, thyroid papillary carcinoma and malignant melanoma [9]. Primary carcinoid tumors found in combination with different types of tumors in other organs, such as in kidney or colon, have been reported in several studies [10-13]. However, a case about carcinoid tumors found in combination with different types of tumor within a lung has never been reported.…”

A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET

“…To date, the literature in English reveals, 20 case reports (18 synchronous cases [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], 2 metachronous cases [25,26]), 2 case series [25,27], 3 review articles [28][29][30], and about 10 retrospective studies [31][32][33][34] or population-based studies from a National Registry [35][36][37][38][39][40][41] of synchronous or metachronous NET with a second primary malignancy (SPM). A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma (Table 1) and 3 patients (including the present study) of 3 articles with metachronous gastrointestinal NET and colorectal adenocarcinoma ( Table 2).…”

“…Pearson and Fitzgerald were the first to report the high incidence (23%) of second primary malignancies (SPM) in patients with small intestinal NETs at autopsy [27]. A certain number of NETs were incidentally found during surgery for other [7] 1972 53 M Rectum Rectum -Lotlikar et al [25] 1981 53 M Rectum Small bowel -Lotlikar et al [25] 1981 67 F Right colon Small bowel -Lotlikar et al [25] 1981 60 F Sigmoid colon Small bowel -Sacchi et al [8] 1988 57 M Right colon Small bowel -Tse et al [9] 1997 72 M Hepatic flexure Small bowel -Habal et al [28] 2000 52 M Sigmoid colon Rectum Cioffi et al [10] 2005 64 F Ileum Small bowel -Klucinski et al [11] 2006 72 F Transverse colon Small bowel -Chemli et al [12] 2007 63 F Right colon Small bowel -Aslam et al [13] 2009 67 F Sigmoid colon Small bowel G1 Boland et al [14] 2009 77 F Left colon Meckel's diverticulum -McHugh et al [15] 2009 74 F Rectum Small bowel -Wohadlo et al [29] 2011 53 M Splenic-hepatic flexure Small bowel -Gurzu et al [16] 2012 78 F Sigmoid colon Small bowel G3 Pozzato et al [17] 2012 61 M Right colon Duodenum G1 Katalinic 2014 et al [18] 2014 63 M Right colon Meckel's diverticulum G1 Zhu et al [19] 2015 64 F Rectum Rectum G1 Almajano et al [20] 2016 66 M Right colon Small bowel G1 Mohapatra et al [21] 2016 83 M Sigmoid colon Left colon G3 Nejatollahi et al [22] 2016 83 M Sigmoid colon Small bowel G1 Vootla et al [23] 2016 46 F Hepatic flexure Rectum G1 Winn et al [30] 2017 40 M Sigmoid colon Rectum G1 Winn et al [30] 2017 70 M Sigmoid colon Rectum G1 Napolitano et al [24] 2017 72 M Right colon Small bowel G1-G2 cancers. The estimated rate of SPM associated with other malignancies was 2.3% in surgical cases and 8.1% in autopsy cases [42].…”