Synchronous occurrence of extramedullary plasmacytoma and squamous cell carcinoma in situ in the larynx: a case report

Zhang, Xiaoli; Li, Daiqiang; Li, Jing-Jia; Li, Shi-Sheng; Yang, Xiaocheng

doi:10.5732/cjc.010.10238

Cited by 4 publications

(3 citation statements)

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“…1 To date, 15 cases of synchronous carcinoma and EP have been published in the English literature. The involved sites of previous reported cases were as follows: upper aerodigestive tract (n = 4), 7,8,13,16 stomach (n = 3), 5,15,17 lung (n = 1), 4 thyroid gland (n = 1), 12 colon (n = 1), 3 breast (n = 1), 6 kidney (n = 1), 14 bladder (n = 1), 10 prostate (n = 1) 11 and uterus (n = 1). 9 The clinical and pathological features of the 15 cases and current case are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Extraosseous plasmacytomas has been described as a rare complication of carcinoma. To date, only 15 cases of carcinoma complicating EP have been reported in the English literature 3‐17 . In contrast, there is increasing evidence that clonal B cells reacting to tumor‐derived antigens proliferate in the cancer stroma.…”

Section: Introductionmentioning

confidence: 99%

“…To date, only 15 cases of carcinoma complicating EP have been reported in the English literature. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] In contrast, there is increasing evidence that clonal B cells reacting to tumor-derived antigens proliferate in the cancer stroma. This might pose a differential diagnosis problem between reactive and neoplastic B cells.…”

Section: Introductionmentioning

confidence: 99%

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Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

Takahara

Satou

Tsuzuki

2020

Pathology International

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Recent studies of tumor microenvironments have revealed that clonal B cells reacting to tumor‐derived antigens play an important role in anti‐tumor immunity. We report a case of a 72‐year‐old Japanese man with a complaint of fever for 1 month. Computed tomography revealed a 48 mm mass in his right kidney. The patient underwent a right nephrectomy and histology revealed clear cell renal cell carcinoma (ccRCC) of Fuhrman Grade 4 with rhabdoid morphology. Focally, marked plasmacytoid cell infiltration was detected in the carcinoma. These plasmacytoid cells were immunohistochemically positive for immunoglobulin (Ig) G, and kappa light chain restriction was confirmed using mRNA in situ hybridization. Programmed death‐ligand 1 (PD‐L1) immunostaining and RNA in situ hybridization of transforming growth factor beta (TGF‐β) revealed that both PD‐L1 and TGF‐β were highly expressed in the area with clonal plasmacytoid cell infiltration. The patient developed bone metastasis 3 months after surgery, and plasmacytoma was not detected during the observation period. We identified a potential link between an immunosuppressive microenvironment and clonal B cell proliferation. The latter posed a differential diagnosis problem between reactive and neoplastic clonal B cell proliferation vis‐à‐vis a plasmacytoma complicating carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

Takahara

Satou

Tsuzuki

2020

Pathology International

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Concomitant Extramedullary Plasmacytoma in the Oropharynx and Hypopharyngeal Squamous Cell Carcinoma

Sato

Yoshimasu

Okamoto

et al. 2018

Case Reports in Otolaryngology

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We report a rare case of hypopharyngeal squamous cell carcinoma occurring synchronously with extramedullary plasmacytoma (EPM) of the oropharynx in which radiotherapy was used as the curative treatment. A 73-year-old man presented with a sore throat that had persisted for 6 months. Examination revealed a superficial, smooth tumorous lesion at the base of his tongue with a red hue in the oropharynx. In addition, a protruding tumor was observed on the mucosal surface in the right piriform recess of the hypopharynx, and computed tomography revealed thickening of the pharyngeal wall at the right tongue base and in the right piriform recess of the hypopharynx. Because no definitive diagnosis could be reached for the lesion at the base of the tongue, the entire tongue-base tumor was resected by transoral surgery under endoscopy. Proliferation of plasma cells in the tumor was detected, and a bone marrow puncture test ruled out multiple myeloma leading to a definitive diagnosis of Stage I (cT1N0M0) squamous cell carcinoma in the right piriform recess of the hypopharynx and primary extramedullary plasmacytoma in the oropharynx. Radiotherapy was selected for curative treatment with a complete response for both cancers. No recurrences have been observed as of 12 months postoperatively.

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Solitary Extramedullary Plasmacytoma of the Larynx and Secondary Laryngeal Involvement in Plasma Cell Myeloma: Single-Centre Retrospective Analysis and Systematic Literature Review

Szczepanek

Drozd-Sokołowska

Sokołowski

et al. 2022

JCM

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The involvement of the larynx in plasma cell myeloma (PCM) may manifest as solitary extramedullary plasmacytoma of the larynx (sEMP-L) or as infiltration of the larynx during newly diagnosed or relapsed systemic disease with bone marrow involvement (plasma cell myeloma with laryngeal involvement, PCM-L). To increase knowledge about these rare conditions, we performed a retrospective analysis along with a comprehensive literature review of cases of sEMP-L or PCM-L. Six patients (two sEMP-L and four PCM-L) were identified in our tertiary laryngological centre from 2009 to 2021, constituting 0.88% of all malignant laryngeal tumours. The literature search yielded 187 cases, including 152 sEMP-L and 35 sPCM-L. A comparison of baseline characteristics between sEMP-L and PCM-L performed in the combined cohort of cases from literature review and retrospective analysis revealed that patients with sEMP-L were younger (56 vs. 64 years, p ≤ 0.001) and presented less commonly with thyroid or cricoid cartilage involvement (2.2% vs. 30.8%, p ≤ 0.001). The prognosis of sEMP-L was better than PCM-L (overall survival 86% vs. 55% at 5 years, p = 0.002). Analysis of potential factors that could influence progression-free survival (PFS) in the group of sEMP-L revealed that male sex and cartilage involvement negatively affected PFS in univariate analyses, while only cartilage involvement retained statistical significance in multivariate analysis (HR = 19.94, p = 0.024). In conclusion, PCM with laryngeal involvement is sporadic. Secondary involvement of the larynx during PCM might be more common than sEMP-L and is associated with worse survival. The involvement of cartilage adversely influences the outcome of sEMP-L.

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Synchronous occurrence of extramedullary plasmacytoma and squamous cell carcinoma in situ in the larynx: a case report

Cited by 4 publications

References 0 publications

Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

Concomitant Extramedullary Plasmacytoma in the Oropharynx and Hypopharyngeal Squamous Cell Carcinoma

Solitary Extramedullary Plasmacytoma of the Larynx and Secondary Laryngeal Involvement in Plasma Cell Myeloma: Single-Centre Retrospective Analysis and Systematic Literature Review

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