Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

Abstract

After chemotherapy and radiotherapy for nonHodgkin's lymphoma during a one-year period, a 66-year-old mandeveloped synchronous triple lung cancers in both lungs. Of the three resected tumors, one was advanced large cell carcinoma with neuroendocrine morphology, and the other two were early squamouscell carcinoma without lymph node metastasis. Although he received repeated chemotherapy for lung cancer, the patient died of hepatic failure due to multiple liver metastases. Autopsy revealed disseminated metastasis of the large cell carcinoma with neuroendocrine morphology throughout the entire body, but no recurrence of malignant lymphoma or squamouscell carcinoma was found. To our knowledge, this is the first report of triple lung cancers occurring after treatment for malignant lymphoma.

Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report and literature review

“…In the 2005 multicenter clinical study (13 centers, with 109,000 cases of NHL) by Brennan et al (22), the incidence of NHL secondary to other primary malignancies was considerably higher than that of the normal population. However, the association between the NHL subtypes and the pathological types of primary lung malignancies is not clear when reviewing the existing literature reports; diffuse large B-cell lymphoma combined with lung squamous cell carcinoma is reported more frequently, followed by SCLC, adenocarcinoma and large cell lung cancer (2,(23)(24)(25).…”

Synchronous Triple Primary Lung Cancer: A Rare Case with Radiologic-Pathologic Correlation

“…Multiple synchronous primary lung cancer is rare with a low and variable incidence rate of 1-16% (2). Furthermore, the reported incidence of synchronous triple lung cancers is approximately 0.02% (3). We reported the case of a patient with synchronous triple and histologically different primary lung cancers.…”