Syndecan‐1 Expression During the Formation of Junctional Epithelium

Dias, Rubia A.; Shibata, Shunichi; Hashimoto-Uoshima, Mariko; Podyma‐Inoue, Katarzyna Α.; Ishikawa, Isao; Yanagishita, Masaki

doi:10.1902/jop.2005.76.5.696

Cited by 17 publications

(29 citation statements)

References 35 publications

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“…In mesenchymal cells the syndecan-1 level is usually low, but it is elevated transiently during embryonal morphogenesis (68–72) concomitant with a loss of syndecan-1 in the adjacent epithelium. Given this low syndecan-1 level in mesenchymal tumors, the expression, and function of syndecan-1 is far less studied than in carcinomas.…”

Section: Syndecan-1 In Mesenchymal Tumorsmentioning

confidence: 99%

The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors

Szatmári

Dobra

2013

Front. Oncol.

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Proteoglycans (PGs) and in particular the syndecans are involved in the differentiation process across the epithelial-mesenchymal axis, principally through their ability to bind growth factors and modulate their downstream signaling. Malignant tumors have individual proteoglycan profiles, which are closely associated with their differentiation and biological behavior, mesenchymal tumors showing a different profile from that of epithelial tumors. Syndecan-1 is the main syndecan of epithelial malignancies, whereas in sarcomas its expression level is generally low, in accordance with their mesenchymal phenotype and highly malignant behavior. This proteoglycan is often overexpressed in adenocarcinoma cells, whereas mesothelioma and fibrosarcoma cells express syndecan-2 and syndecan-4 more abundantly. Increased expression of syndecan-1 in mesenchymal tumors changes the tumor cell morphology to an epithelioid direction whereas downregulation results in a change in shape from polygonal to spindle-like morphology. Although syndecan-1 plays major roles on the cell-surface, there are also intracellular functions, which are not very well studied. On the functional level, syndecan-1 affects mesenchymal tumor cell proliferation, adhesion, migration and motility, and the effect varies with the different domains of the core protein. Syndecan-1 may exert stimulatory or inhibitory effects, depending on the concentration of various mitogens, enzymes, and signaling molecules, the ratio between the shed and membrane-associated syndecan-1 and histological grade of the tumour. Growth factor signaling seems to be delicately controlled by regulatory loops involving the syndecan expression levels and their sulfation patterns. Overexpression of syndecan-1 modulates the biosynthesis and sulfation of heparan sulfate and it also affects the expression of other PGs. On transcriptomic level, syndecan-1 modulation results in profound effects on genes involved in regulation of cell growth

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Section: Syndecan-1 In Mesenchymal Tumorsmentioning

confidence: 99%

The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors

Szatmári

Dobra

2013

Front. Oncol.

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“…In wounds that are remodeling over a period of weeks, perlecan levels in the subepithelial connective tissues appear to remain relatively high (SundarRaj et al, 1998). Perlecan has been demonstrated in periodontal ligament fibroblasts (Larjava et al, 1992), and its heparan-sulfatedecorated cell-surface homologues, the syndecans 1-4, have been detected in association with the formation of junctional epithelium (Dias et al, 2005). Perlecan has also been detected in the basement membranes of human tissues, including the pituitary gland, skin, breast, thymus, prostate, colon, liver, pancreas, spleen, heart, and lung.…”

Section: Perlecan a Heparan Sulfate Proteoglycanmentioning

confidence: 99%

The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures

DeCarlo

Whitelock

2006

J Dent Res

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Tissue engineering, grafting procedures, regeneration, and tissue remodeling are developing therapeutic modalities with great potential medical value, but these regenerative modalities are not as effective or predictable as clinicians and patients would like. Greater understanding of growth factors, cytokines, extracellular matrix molecules, and their roles in cell-mediated healing processes have made these regenerative therapies more clinically viable and will continue advancing the fields of tissue engineering and grafting. However, millions of oral and non-oral bone-grafting procedures are performed annually, and only a small percentage yield the most desirable results. Here we review the heparan-sulfate-decorated extracellular biomolecule named perlecan and the research relating to its potential as an adjunct in bone-regenerative procedures. The review includes an overview of bone graft substitutes and biological adjuncts to bone-regenerative procedures in medicine as they apply to periodontal disease, alveolar ridge augmentation, and barrier membrane therapy. Perlecan is discussed as a potential biological adjunct in terms of growth factor sequestration and delivery, and promoting cell adhesion, proliferation, differentiation, and angiogenesis. Further, we propose delivery and application schemes for perlecan and/or its domains in bone-regenerative procedures, with particular emphasis on its heparan-sulfate-decorated domain I. The perlecan molecule, with its heparan sulfate glycosylation, may provide a multi-faceted approach for the delivery of a more comprehensive stimulus than other single potential adjuncts currently available for bone-regenerative procedures.

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“…It is involved in epithelial–mesenchymal interactions regulating growth, compartmentalization, and determination of dental mesenchymal cell lineage during early tooth development 2‐5 . Studies related to syndecan‐1 expression of postnatal tooth development have focused on epithelial cells, 6‐9 the periodontium, 10 and the wound‐healing process 11,12 . We recently demonstrated that syndecan‐1 is an important molecule during the formation of junctional epithelium 7 .…”

mentioning

confidence: 99%

“…Studies related to syndecan‐1 expression of postnatal tooth development have focused on epithelial cells, 6‐9 the periodontium, 10 and the wound‐healing process 11,12 . We recently demonstrated that syndecan‐1 is an important molecule during the formation of junctional epithelium 7 . These studies indicated that syndecan‐1 expression is important for cell biology and for clinical applications in the field of dentistry.…”

mentioning

confidence: 99%

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Immunohistochemical Localization of Syndecan‐1 in the Dental Follicle of Postnatal Mouse Teeth

Shibata

Dias

Hashimoto-Uoshima

et al. 2007

Journal of Periodontology

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Syndecan‐1 Expression During the Formation of Junctional Epithelium

Abstract: Results of syndecan-1 mRNA and protein expression patterns suggested that this proteoglycan might be an important molecule during the formation of JE.

Cited by 17 publications

References 35 publications

The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors

The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors

The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures

Immunohistochemical Localization of Syndecan‐1 in the Dental Follicle of Postnatal Mouse Teeth

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