Syndecan-3 in limb skeletal development

Kosher, Robert A.

doi:10.1002/(sici)1097-0029(19981015)43:2<123::aid-jemt5>3.0.co;2-g

Cited by 43 publications

(21 citation statements)

References 90 publications

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“…Syndecan-3 is expressed in the chicken brain (Gould et al, 1995), and has been suggested to mediate the formation of neuronal connections during development (Goutebroze et al, 2003) and act as a receptor for the axonal growth factor, pleiotrophin (Raulo et al, 1994). In addition, syndecan-3 is expressed during development in the chicken, and regulates limb outgrowth, skeletal development, and muscle regeneration (Cornelison et al, 2001;Gould et al, 1992;Kosher, 1998).…”

Section: Introductionmentioning

confidence: 52%

The role of syndecans in disease and wound healing

2006

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Section: Introductionmentioning

confidence: 52%

The role of syndecans in disease and wound healing

2006

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“…The results of our study in adult human joints show that syndecan-3 is expressed in RA and nonrheumatoid synovium; it is also expressed by chondrocytes in normal and OA articular cartilage, and it is a regulator of chondrocyte proliferation (50,62). Furthermore, syndecan-3 is involved in limb morphogenesis and skeletal development, including chondrogenesis and joint formation, and skeletal muscle regeneration (63,64).…”

Section: Discussionmentioning

confidence: 68%

Induction of a CXCL8 binding site on endothelial syndecan‐3 in rheumatoid synovium

Patterson

Gardner

Shaw

et al. 2005

Arthritis & Rheumatism

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“…Syndecan-3 was first identified on neuronal cells and has been associated with the generation of cerebellar fibrillar plaques in Alzheimer disease 10. It is also an HSPG of the musculoskeletal system 11 – 14. Glypicans are widely expressed in embryonic and adult tissues such as ovary, intestine and central nervous system, and are involved in growth factor signalling 15.…”

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confidence: 99%

Differential expression of syndecans and glypicans in chronically inflamed synovium

Patterson

Cartwright

Gourichon

et al. 2007

Annals of the Rheumatic Diseases

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Background:Membrane-bound heparan sulphate proteoglycans (HSPGs) act as co-receptors and presenters of cytokines and are involved in cell–matrix and cell–cell adhesion.Aim:To investigate which HSPGs are expressed in knee joint synovia from patients with different forms of arthritis and normal individuals.Methods:Synovial samples were obtained from patients with early rheumatoid arthritis (n = 8), longstanding rheumatoid arthritis (n = 13), psoriatic arthritis (n = 7), osteoarthritis (n = 6) and normal joints (n = 12). Expression of syndecan-1, -2, -3 and -4 and glypican-1, -3 and -4 was analysed by immunohistochemistry and dual label immunofluorescence.Results:The expression of HSPGs in chronically inflamed synovium exhibited a differential distribution. Syndecan-1 was present in the mononuclear infiltrates of synovia from patients with rheumatoid and psoriatic arthritis where it was expressed by plasma cells. Syndecan-2 was present mainly in blood vessels where it occurred on endothelial cells, pericytes and smooth muscle cells. Syndecan-3 stained intensely in endothelial cells but also occurred in sublining macrophages and the lining layer. Glypican-4 occurred in the lining layer and blood vessels. Increased expression of these HSPGs was apparent in rheumatoid and psoriatic compared to osteoarthritic and normal synovia. Little or no staining for syndecan-4, glypican-1 and glypican-3 was seen in all samples.Discussion:Selected HSPGs, such as syndecan-1, -2 and -3 and glypican-4, could play a part in the pathophysiology of arthritis, such as the migration and retention of leukocytes and angiogenesis in the chronically inflamed synovium.

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Syndecan-3 in limb skeletal development

Cited by 43 publications

References 90 publications

The role of syndecans in disease and wound healing

The role of syndecans in disease and wound healing

Induction of a CXCL8 binding site on endothelial syndecan‐3 in rheumatoid synovium

Differential expression of syndecans and glypicans in chronically inflamed synovium

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