Syndrome Evaluation System (SES) versus Blood Culture (BACTEC) in the Diagnosis and Management of Neonatal Sepsis - A Randomized Controlled Trial

Bhat, B. Vishnu; Prasad, Priyanka Sheshnath; Kumar, Venkata Banda Ravi; Harish, Belgode Narasimha; Krishnakumari, K.; Anand, Rekha; Manjunath, GV; Adhisivam, B; Shruthi, Basavaradhya S.

doi:10.1007/s12098-015-1956-3

Cited by 24 publications

(15 citation statements)

References 35 publications

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“…This study also demonstrates the relatively low sensitivity of blood cultures for detecting bacteraemia in this age group. Other studies hold promise for advanced polymerase chain reaction‐based methods that may be more sensitive than current methods .…”

Section: Discussionmentioning

confidence: 99%

Using anaerobic blood cultures for infants younger than 90 days rarely showed anaerobic infections but increased yields of bacterial growth

Gross¹,

Gordon²,

Benenson

et al. 2018

Acta Paediatrica

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Section: Discussionmentioning

confidence: 99%

Using anaerobic blood cultures for infants younger than 90 days rarely showed anaerobic infections but increased yields of bacterial growth

Gross¹,

Gordon²,

Benenson

et al. 2018

Acta Paediatrica

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“…In 2 randomized intervention studies by Tafelski et al and Bhat et al, there were significantly fewer adjustments made when using SeptiFast (13.5% vs 9.8%) [ 20 , 21 ] and another intervention study by Cambau et al found a significant increase in the use of appropriate antimicrobials (23.6% vs 33.6%) [ 22 ]. In prospective studies by Mancini et al and Tschiedel et al, the use of SeptiFast resulted in higher rates of antibiotic changes [ 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

The Clinical Impact of Rapid Molecular Microbiological Diagnostics for Pathogen and Resistance Gene Identification in Patients With Sepsis: A Systematic Review

D’Onofrio

Salimans

Bedenić

et al. 2020

Open Forum Infectious Diseases

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Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared to blood cultures. PubMed was searched for clinical studies using either whole blood directly or after short-term incubation. Twenty-five articles were retrieved describing the outcomes of eight different MDx. Three interventional studies showed a significant increase in appropriateness of antimicrobial therapy, and a non-significant change in time to appropriate therapy. Impact on mortality was conflicting. Length-of-stay was significantly lower in two studies. A significant decrease in antimicrobial cost was demonstrated in six studies. Limitations of this systematic review include the low number and observed heterogeneity of clinical studies. In conclusion, potential benefits of MDx regarding antimicrobial management and some patient outcomes were reported. More rigorous intervention studies are needed focusing on the direct benefits for patients.

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“…The laboratory strives to provide rapid pathogen identification, with which providers can optimize antimicrobial utilization and improve patient outcomes. The use of rapid diagnostics performed on positive blood culture broths revealed the effect on sepsis mortality and operational outcomes for adult and pediatric patients with bacteremia or fungemia (2,3,15,(17)(18)(19)(20)(21). In other studies, only operations and costs of care were assessed (13,22).…”

Section: Clinical Microbiology Laboratory's Role In Value-based Care mentioning

confidence: 99%

“…In cases of sepsis, rapid intervention with appropriate antimicrobial therapy can be critical to patient survival (30)(31)(32). In reports describing mortality for bloodstream infection caused by aerobes, anaerobes, and fungi, appropriate antibiotic therapy increases survival by over 25% (2,3,15,(17)(18)(19)(20)(21)18). Eliminating delays in appropriate antibiotic administration is said to increase survival by approximately 7%-10% per hour (33).…”

Section: Mini-reviewsmentioning

confidence: 99%

Rapid Diagnostics for Blood Cultures: Supporting Decisions for Antimicrobial Therapy and Value-Based Care

Wolk

Johnson

2019

The Journal of Applied Laboratory Medicine

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Bacteremia and sepsis are critically important syndromes with high mortality, morbidity, and associated costs. Bloodstream infections and sepsis are among the top causes of mortality in the US, with >600 deaths each day. Most septic patients can be found in emergency medicine departments or critical care units, settings in which rapid administration of targeted antibiotic therapy can reduce mortality. Unfortunately, routine blood cultures are not rapid enough to aid in the decision of therapeutic intervention at the onset of bacteremia. As a result, empiric, broad-spectrum treatment is common-a costly approach that may fail to target the correct microbe effectively, may inadvertently harm patients via antimicrobial toxicity, and may contribute to the evolution of drug-resistant microbes. To overcome these challenges, laboratorians must understand the complexity of diagnosing and treating septic patients, focus on creating algorithms that rapidly support decisions for targeted antibiotic therapy, and synergize with existing emergency department and critical care clinical practices put forth in the Surviving Sepsis Guidelines. IMPACT STATEMENTPatients infected with bacteria in their bloodstream can benefit from deployment of laboratory technology that is more rapid and more accurate than historical methods. This review will characterize the current and novel laboratory technology and the potential effect of technology to improve care for patients with blood stream infections. The review provides a snapshot of emerging technologies for laboratorians to consider as they strategize about how best to support quality initiatives focusing on sepsis in their organizations.

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Syndrome Evaluation System (SES) versus Blood Culture (BACTEC) in the Diagnosis and Management of Neonatal Sepsis - A Randomized Controlled Trial

Abstract: This new molecular based diagnostic system (SES) helps in rapid and accurate diagnosis of neonatal sepsis and reduces mortality and morbidity in affected neonates.

Cited by 24 publications

References 35 publications

Using anaerobic blood cultures for infants younger than 90 days rarely showed anaerobic infections but increased yields of bacterial growth

Using anaerobic blood cultures for infants younger than 90 days rarely showed anaerobic infections but increased yields of bacterial growth

The Clinical Impact of Rapid Molecular Microbiological Diagnostics for Pathogen and Resistance Gene Identification in Patients With Sepsis: A Systematic Review

Rapid Diagnostics for Blood Cultures: Supporting Decisions for Antimicrobial Therapy and Value-Based Care

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