Synergism Between Growth-Factors in the Control of Glioma Cell-Proliferation, Migration and Invasion in-Vitro

Merzak, Abderrahim; Koochekpour, Shahriar; Dkhissi, Fatima; Raynal, Stéphane; Lawrence, Daniel A.; Pilkington, G. J.

doi:10.3892/ijo.6.5.1079

Cited by 11 publications

(11 citation statements)

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“…Transforming growth factor-β1 An additional factor, TGF-β1, has been shown to both regulate the mitogenic potential of other growth factors and increase invasiveness of glial tumors in vitro [8,17]. Recent reports now suggest that TGF-β1 exert its effects on the invasive property of glioblastoma cells via up-regulation of α2-integrin subunit expression [49].…”

Section: Granulocyte Colony-stimulating Factormentioning

confidence: 97%

“…In addition, both autocrine and paracrine growth factor stimulation of sub-populations of neoplastic glia may result in neoplastic cell-derived ECM secretion. Growth factors may, in fact, be major mediators of many of the mechanisms involved in the invasion cascade [17]. Following adhesion to, and migration on, ECM components, it is necessary for these to be degraded or remodeled by proteases.…”

Section: Mechanisms Of Migration and Invasionmentioning

confidence: 99%

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Migration and invasion in brain neoplasms

Bolteus

Berens

Pilkington

2001

Curr Neurol Neurosci Rep

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Local invasion of the brain by neoplastic glial cells is a major obstacle to effective treatment of intrinsic brain tumors. Invasion is directly related to histologic malignancy, but occurs to some extent irrespective of tumor grade. Because the brain-to-tumor interface is not well demarcated, total surgical removal is rarely possible; moreover, as invading cells transiently arrest from cell division they are refractory to radiotherapeutic intervention. Invading cells may also be protected from the action of cytotoxic drugs by the presence of an intact blood-brain barrier. The invading cells, having migrated several millimeters or even centimeters from the main focus of the tumor, return to cycle phase under the control of some as yet unknown microenvironmental cue to form a recurrent tumor adjacent to the original site of presentation. Recent cellular and genetic information concerning factors underlying invasion may not only yield suitable targets for adaptation of existing therapies, but may also lead to novel approaches in glioma management.

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Section: Granulocyte Colony-stimulating Factormentioning

confidence: 97%

Section: Mechanisms Of Migration and Invasionmentioning

confidence: 99%

Migration and invasion in brain neoplasms

Bolteus

Berens

Pilkington

2001

Curr Neurol Neurosci Rep

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“…In another study, different concentrations and different combinations of growth factors gave varied responses with respect to proliferation and invasion of gliomas in vitro suggesting synergism-antagonism between growth factors. Indeed, both negative and positive effects of TGF-β1 on the mitogenic actions of EGF, PDGF and bFGF were seen on a pilocytic astrocytoma cell line (Merzak et al, 1995) while only a negative effect was reported on the mitogenic action of these other growth factors on malignant glioma cell lines, except when it was combined with bFGF (Merzak et al, 1994).…”

Section: mentioning

confidence: 99%

The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells

Rooprai¹,

Rucklidge²,

Panou³

et al. 2000

Br J Cancer

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Matrix metalloproteinases (MMPs) are a growing family of zinc-dependent endopeptidases that are capable of degrading various components of the extracellular matrix. These enzymes have been implicated in a variety of physiological and pathological conditions including embryogenesis and tumour invasion. The synthesis of many MMPs is thought to be regulated by growth factors, cytokines and hormones. In this study, we investigated the effects of five exogenous growth factors known to be expressed by gliomas [epidermal growth factor (EGF), basic growth factor (bFGF), transforming growth factor beta (TGF-β1,2) and vascular endothelial growth factor (VEGF)] on MMP-2 and MMP-9 expression in an ependymoma, two grade III astrocytomas, a grade III oligoastrocytoma and a benign meningioma. Zymogram analysis revealed that the effects of the growth factors depended upon the cell lines used in the study. Growth factors generally up-regulated MMP-2 and MMP-9 expression in the gliomas but were least effective in the meningioma; the effect being most prominent with TGF-β1 and TGF-β2 in all the cell lines. It is hypothesized that paracrine growth factor interplay may be crucial in the regulation of MMP expression by glioma invasion of the normal brain. © 2000 Cancer Research Campaign

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“…With the exception of some morphological changes, we have no clear evidence for induction of differentiation or senescence by autocrine IL-1 in our experiments, and further studies in this area are necessary. This (McKinnon et al, 1993) also draws attention to the fact that multiple growth factors can influence glioblastoma growth, some of them acting synergistically (Merzak et al, 1995). In this respect, it is of interest that our glioblastoma cell lines constitutively express messages for cytokines known to act antiproliferatively such as TGF-b and TNF (data not shown).…”

Section: Expression and Function Of Il-1ra In Glioblastomasmentioning

confidence: 99%