Synergistic centrally mediated cardiovascular effects of a kappa opioid agonist and an α2-adrenoceptor agonist

Shen, Su; Ingenito, Alphonse J.

doi:10.1016/s0306-3623(99)00041-5

Cited by 1 publication

(1 citation statement)

References 45 publications

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“…Among them, excitatory and inhibitory amino acids, several neuropeptides and amines (glutamate, GABA, vasopressin, oxytocin, somatostatin, opioid peptides, substance P, angiotensin II, acetylcholine, L-proline, catecholamines and serotonin), which modify cardiovascular parameters when they are microinjected into the NTS [5,11,36,40,43,64,71,73,82,109,122,126,127,167,191,200,203], might be involved in the processing of messages for the reflex control of cardiovascular function. In this review, beyond serotonin, some emphasis will also be put on glutamate, GABA, and substance P, because in most species including the rat, there is a general agreement regarding their effective involvement in the reflex control of cardiovascular function.…”

Section: Neurotransmitters and Their Res-pective Receptors Involved Imentioning

confidence: 99%

The Key Role of Medullary 5-HT3 Receptors in the Serotonin-Mediated Neural Control of Cardiovascular Function

Sévoz‐Couche¹,

Machado²,

Hamon³

et al. 2005

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The baroreceptor reflex plays a crucial role in the homeostatic control of cardiovascular parameters. In the central nervous system, the nucleus of the tractus solitarius (NTS) is critically involved in cardiovascular reflex control because it is both the first site of termination of glutamatergic baroreceptor afferent fibres and an important integrative area for the sensory afferent signals reaching the brainstem. In addition to glutamate, the NTS contains numerous neurotransmitters that could participate in the modulations of the baroreceptor reflex sensitivity which occur under various physiological conditions. In particular, a large body of evidence indicates that serotonin plays a modulatory role in the central control of blood pressure, especially at the level of the NTS, which is innervated by both central and peripheral serotonergic fibres. Indeed, serotonin exerts multiple cardiovascular influences through the activation of several receptors in the NTS. Actually, the NTS is the central area endowed with the highest density of serotonin 3 (5-HT 3 ) receptors whose stimulation triggers all the adaptive cardiovascular changes normally associated with behavioural responses to various stressful conditions.In this review, we first assess the current knowledge about the mechanisms underlying the cardiovascular effects of the specific activation of serotonergic receptors in the NTS. Secondly, we describe evidence that, in the NTS, 5-HT 3 receptors play a key role in one of the crucial homeostatic responses that characterise the defence reaction: the inhibitory modulation of the parasympathetic cardiac component of the baroreceptor reflex. The possible functional interactions of 5-HT 3 receptors with GABA A , NK 1 and NMDA receptors within the NTS are also discussed.

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Section: Neurotransmitters and Their Res-pective Receptors Involved Imentioning

confidence: 99%

The Key Role of Medullary 5-HT3 Receptors in the Serotonin-Mediated Neural Control of Cardiovascular Function

Sévoz‐Couche¹,

Machado²,

Hamon³

et al. 2005

View full text Add to dashboard Cite

show abstract

Synergistic centrally mediated cardiovascular effects of a kappa opioid agonist and an α2-adrenoceptor agonist

Cited by 1 publication

References 45 publications

The Key Role of Medullary 5-HT3 Receptors in the Serotonin-Mediated Neural Control of Cardiovascular Function

The Key Role of Medullary 5-HT3 Receptors in the Serotonin-Mediated Neural Control of Cardiovascular Function

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