Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε‑caprolactone)-poly(ethylene oxide) and F127®

Abstract

Binary mixtures of block copolymers E 114 CL 20 and E 97 P 69 E 97 (F127 ® ) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E 114 CL 20 mixtures (30-50 wt.%) were observed by addition of the diblock E 114 CL 20 , also reaching the best enhancement of drug solubility for mangiferin and carbamazepine. Experimental MaterialsCopolymer E 114 CL 20 (CL 20 ) (E = ethylene oxide and CL = ε-caprolactone blocks) was synthesized and Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127 ® J. Braz. Chem. Soc. 1342