Synergistic effect of caffeic acid phenethyl ester with caspofungin against Candida albicans is mediated by disrupting iron homeostasis

Sun, Libo; Hang, Chengcheng; Liao, Kai

doi:10.1016/j.fct.2018.04.014

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…However, all combinations evidenced indifferent interactions. These results are in contrast with the previous findings by , where CAPE synergistically enhanced the antifungal activity of fluconazole against resistant C. albicans [80]. Furthermore, the synergistic effect between CAPE and caspofungin against C. albicans through disrupting iron homeostasis has already been described [80].…”

Section: Discussioncontrasting

confidence: 94%

“…These results are in contrast with the previous findings by , where CAPE synergistically enhanced the antifungal activity of fluconazole against resistant C. albicans [80]. Furthermore, the synergistic effect between CAPE and caspofungin against C. albicans through disrupting iron homeostasis has already been described [80]. These differences can be related to different growth conditions, purity of the compounds, and origin of the strains.…”

Section: Discussioncontrasting

confidence: 87%

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Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

Rossatto

Tharmalingam

Escobar

et al. 2021

JoF

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Candida auris is an emerging healthcare-associated fungal pathogen that has become a serious global health threat. Current treatment options are limited due to drug resistance. New therapeutic strategies are required to target this organism and its pathogenicity. Plant polyphenols are structurally diverse compounds that present a vast range of biological properties. In the present study, plant-derived molecules ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) were investigated for their antifungal and antivirulence activities against Candida auris. We also tested against C. albicans. The minimum inhibitory concentration (MIC) for EA ranged from 0.125 to 0.25 µg/mL and for CAPE ranged from 1 to 64 µg/mL against drug-resistant C. auris strains. Killing kinetics determined that after 4 h treatment with CAPE, there was a complete reduction of viable C. auris cells compared to fluconazole. Both compounds might act by modifying the fungal cell wall. CAPE significantly reduced the biomass and the metabolic activity of C. auris biofilm and impaired C. auris adhesion to cultured human epithelial cells. Furthermore, both compounds prolonged the survival rate of Galleria mellonella infected by C. auris (p = 0.0088 for EA at 32 mg/kg and p = 0.0028 for CAPE at 4 mg/kg). In addition, EA at 4 μg/mL prolonged the survival of C. albicans-infected Caenorhabditis elegans (p < 0.0001). CAPE was not able to prolong the survival of C. albicans-infected C. elegans. These findings highlight the antifungal and antivirulence effects of EA and CAPE against C. auris, and warrant further investigation as novel antifungal agents against drug-resistant infections.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussioncontrasting

confidence: 87%

Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

Rossatto

Tharmalingam

Escobar

et al. 2021

JoF

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“…Because of the limited numbers of antifungal drugs, undesirable toxic side effects, and the emergence of resistant strains, the treatment of candidiasis faces an enormous clinical challenge [25]. However, some natural molecules showing promising antifungal properties could be considered as an important source for development of novel anti-Candida therapy [26][27][28]. During the last decade, honokiol has been reported to have potent anticancer and antimicrobial activities, including anti-Candida activities [12].…”

Section: Discussionmentioning

confidence: 99%

Opposite effects of vitamin C and vitamin E on the antifungal activity of honokiol

Sun

Ding

et al. 2019

Journal of Microbiology and Biotechnology

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The aim of the present study was to evaluate the effects of two well-known natural antioxidants, vitamin C (VC) and vitamin E (VE), on the antifungal activity of honokiol against Candida albicans. The broth microdilution method was employed to test the antifungal activities of honokiol with or without antioxidants in the medium against C. albicans strain. Intracellular reactive oxygen species and lipid peroxidation were determined by fluorescence staining assay. Mitochondrial dysfunction was assessed by detecting the mitochondrial DNA and the mitochondrial membrane potential. We observed that VC could significantly potentiate the antifungal activities of honokiol while VE reduced the effectiveness of honokiol against C. albicans. In addition, VC accelerated honokiol-induced mitochondrial dysfunction and inhibited glycolysis leading to a decrease in cellular ATP. However, VE could protect against mitochondrial membrane lipid peroxidation and rescue mitochondrial function after honokiol treatment. Our research provides new insight into the understanding of the action mechanism of honokiol and VC combination against C. albicans.

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“…CAPE has antifungal, antibacterial, and antiviral activity. It prolongs the survival of mice [ 96 ] and Caenorhabditis elegans infected with C. albicans [ 97 ], and works synergistically with antifungal drugs like caspofungin, fluconazole [ 98 ], and amphotericin B [ 99 ]. CAPE is effective against Gram-positive bacteria like S. aureus, Enterococcus faecalis , and Listeria monocytogenes [ 100 ], bee infecting Paenibacillus larvae [ 101 ], common oral cariogenic bacteria ( Streptococcus mutans, Streptococcus sobrinus, Actinomyces viscosus , and Lactobacillus acidophilus ) [ 102 , 103 ], and Gram-negative Vibrio cholerae [ 104 ] and E. coli [ 105 ].…”

Section: Propolis Types Key Molecules and Their Biological Activitiesmentioning

confidence: 99%

Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies

Šuran

Cepanec²,

Mašek

et al. 2021

Molecules

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Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the botanical and geographical origin of propolis. These bioactive molecules have been studied individually and as a part of propolis extracts, as they can be used as representative markers for propolis standardization. Here, we compare the pharmacological effects of representative polyphenols and whole propolis extracts. Based on the literature data, polyphenols and extracts act by suppressing similar targets, from pro-inflammatory TNF/NF-κB to the pro-proliferative MAPK/ERK pathway. In addition, they activate similar antioxidant mechanisms of action, like Nrf2-ARE intracellular antioxidant pathway, and they all have antimicrobial activity. These similarities do not imply that we should attribute the action of propolis solely to the most representative compounds. Moreover, its pharmacological effects will depend on the efficacy of these compounds’ extraction. Thus, we also give an overview of different propolis extraction technologies, from traditional to modern ones, which are environmentally friendlier. These technologies belong to an open research area that needs further effective solutions in terms of well-standardized liquid and solid extracts, which would be reliable in their pharmacological effects, environmentally friendly, and sustainable for production.

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Synergistic effect of caffeic acid phenethyl ester with caspofungin against Candida albicans is mediated by disrupting iron homeostasis

Cited by 13 publications

References 25 publications

Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

Opposite effects of vitamin C and vitamin E on the antifungal activity of honokiol

Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies

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