Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides

Li, Diqiu; Wu, Xiwei; Yu, Xiang; Huang, Qingchun; Tao, Liming

doi:10.1016/j.etap.2014.12.015

Cited by 34 publications

(15 citation statements)

References 21 publications

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“…More than additive mixture effects were found for the cytotoxicity of the combination of abamectin and the surfactants Tween ® 80, Soprophor ® BSU and Soprophor ® 3D33, contained in product 1. Previously, such a synergistic effect of the non-ionic surfactants Tween ® 80 and PEG6000 on cytotoxicity of insecticides, including abamectin was described by Li et al (2015). However, the underlying mechanisms of interaction remained unresolved.…”

Section: Discussionmentioning

confidence: 99%

Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro

et al. 2021

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Currently, the authorisation process for plant protection products (PPPs) relies on the testing of acute and topological toxicity only. Contrastingly, the evaluation of active substances includes a more comprehensive set of toxicity studies. Nevertheless, mixture effects of active ingredients and co-formulants may result in increased toxicity. Therefore, we investigated effects of surface active co-formulants on the toxicity of two PPPs focussing on qualitative and quantitative toxicokinetic effects on absorption and secretion. The respective products are based on the active substances abamectin and fluroxypyr-meptyl and were tested for cytotoxicity in the presence or absence of the corresponding surfactants and co-formulants using Caco-2 cells. In addition, the effect of co-formulants on increased cellular permeation was quantified using LC–MS/MS, while potential kinetic mixture effects were addressed by fluorescence anisotropy measurements and ATPase assays. The results show that surface active co-formulants significantly increase the cytotoxicity of the investigated PPPs, leading to more than additive mixture effects. Moreover, analytical investigations show higher efflux ratios of both active substances and the metabolite fluroxypyr upon combination with certain concentrations of the surfactants. The results further point to a significant and concentration-dependent inhibition of Pgp transporters by most of the surfactants as well as to increased membrane fluidity. Altogether, these findings strongly support the hypothesis that surfactants contribute to increased cytotoxicity of PPPs and do so by increasing the bioavailability of the respective active substances.

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Section: Discussionmentioning

confidence: 99%

Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro

et al. 2021

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“…Previous studies reported that glibenclamide has been formulated in the form of liposomes, polymeric particles, and patches. The formulation of the lipid particles loaded glibenclamide for antidiabetics has also been investigated using solid lipids but there was not reported yet regarding formulations with liquid lipids (Li et al, 2015;Maretti et al, 2021;Gonçalves et al, 2016). Diabetes Mellitus is one of the most common diseases in the world.…”

Section: Introductionmentioning

confidence: 99%

“…The compact PEG 6000 at room temperature is similar to that of solid lipids such as stearic acid which is also solid at room temperature. The melting point of PEG 6000 is between 55 -63 • C. PEG 6000 can minimize drug loss and also has an advantage for oral drug delivery (Li et al, 2015) .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Glibenclamide Solid Lipid Submicroparticles Formated by Virgin Coconut Oil and Solid Matrix Surfactant

Mardiyanto¹,

Fithri

Amriani

et al. 2021

sci. technol. indones.

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Glibenclamide has the biopharmaceutics classification system (BCS) class II which has high permeability and low solubility. The solubility of glibenclamide can be enhanced by forming solid lipid nanoparticles (SLN). This research has the aim to prepare and characterize SLN loading glibenclamide. The glibenclamide SLN formula was composed by using the liquid lipid as virgin coconut oil (VCO), PEG 6000 as a solid matrix, tween 80 with various concentrations as a stabilizer, and PEG 400 as co-surfactant. Characterization was conducted by determining the encapsulation efficiency (%EE), size measurement, particle size distribution, and zeta potential of SLN glibenclamide. SLN formation was also tested for its physical stability based on the heating-cooling cycle method. The optimum formula was obtained at the concentration of tween-80 of 1 mg/mL yielding the %EE value of 60.6194%, and pH 6.01. The results of particles diameter analysis were 175.5 ± 10.07 nm with a polydispersity index (PDI) of 0.1270, and zeta potential of +5.9 mV respectively. Stability testing by the heating-cooling cycle method has shown the instability of the SLN glibenclamide form under extreme temperatures and mechanics. It could be concluded that the results of characterization of glibenclamide SLN showed appropriate physical properties for nanoparticulate formulation.

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“…Among all materials for nanoultrasound contrast agents, protein materials may cause allergic reactions (Chicken et al, 2007). Many stationary agents or surfactants, such as glutaraldehyde and tweens, are harmful to humans, while macromolecular materials pose potential risks to human safety (Zeiger et al, 2005;Li et al, 2015). Therefore, there is an urgent need to prepare nanoscale drug-loaded ultrasound contrast agents with high safety and definite efficacy.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

et al. 2020

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2020) Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo, Drug Delivery, 27:1, 469-481, ABSTRACTAs an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) in vivo. The experimental results showed that the BCNDs were successfully prepared with high biosafety in vivo and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX in vivo and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic. ARTICLE HISTORY

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Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides

Cited by 34 publications

References 21 publications

Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro

Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro

Formulation and Characterization of Glibenclamide Solid Lipid Submicroparticles Formated by Virgin Coconut Oil and Solid Matrix Surfactant

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

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