Synergistic Interaction between Cholesterol and Functionalized Ionic Liquid Based Surfactant Leading to the Morphological Transition

Abstract

Stable vesicular aggregate is the primary requisite to transport and deliver the biological and pharmaceutical standards. The serendipitous discovery of nonlipid vesicles made with the nonlipid building blocks, such as ionic liquid based surfactants (ILBSs) proved to be advantageous over others. In a quest to achieve stable, more rigid and hydrophobic vesicles from ILBSs, here we have investigated the lipid (cholesterol) induced unilamellar vesicle formation in the aqueous functionalized and nonfunctionalized ILBSs. The vesicles show outstanding stability with time, temperature and dilution with water. Spectroscopic (turbidity, steady state absorbance and fluorescence), scattering (dynamic light scattering) and microscopic (transmission electron microscopy) techniques were used to characterize the vesicles. The hydration behavior and rigidity associated with the vesicular bilayer on transforming from micellar assembly was characterized through steady state absorbance and fluorescence techniques. The unilamellar vesicles derived are compared with the conventional surfactant, i. e. cetyltrimethyl ammonium bromide.[a] Dr.

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

“…The self-assembly behaviour of CetPySal in aqueous medium was performed using multi technique approach. [32][33][34][35][36]48] Surface active and micellization parameters derived from the surface tension and conductivity measurements are reported in Table 1 and are compared with precursor surfactant CPCl. [48] Plots of surface tension and specific conductivity (k) versus [CetPySal] are shown in Figure 1.…”

“…As reported, presence of counterions, i. e. Na + and Br À forms the looped conformation which is absent in the salt free catanionic system composed of the same cation (from cationic surfactant) and anion (hydrotope). [33,53] Looking at these characteristics of the catanionic systems, in the present investigation, we had designed ionic liquid based surfactant, CetPySal that forms ionogel at higher concentration and offer micellar transition (from spherical micelles to wormlike micelles to ionogel) as a function of concentration in water.…”

“…Our group is engaged in designing various amphiphilic molecules for their tailor made interfacial and micellar properties, ionic liquid based surfactants (ILBS) with better surface active and micellar properties than the traditional surfactants are one of them. [30][31][32][33][34][35][36] Herein we had designed salicylate based IL (Figure 1a), cetylpyridinium salicylate (CetPySal) that show better surface active and micellar properties than its precursor surfactant cetylpyridinium chloride (CPCl) and exhibited temperature responsive gel-to-gel phase transition. The cationic precursors of the CetPySal, CPCl is known for the antiseptic and antibacterial activity as well as have applications in various fields including mouthwashes, toothpastes and in various pharmaceutical formulations among others.…”

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

“…Other applications of SAILs can be listed as foaming and antifoaming agents, antimicrobials, demulsification of crude oil, chromatographic and electrophoretic separations, enhanced oil recovery (EOR), solubilization of drugs, extraction of natural products etc. (Shah et al, 2018a , 2020 ; Vaid et al, 2018a , b ; Dani et al, 2019 ; Isosaari et al, 2019 ; Kuddushi et al, 2019 , 2020 ; Shakeel et al, 2019 ; Lee et al, 2020 ; Nandwani et al, 2020 ; El Seoud et al, 2021 ). SAILs can be of different kinds based upon their structure.…”

Salt‐Induced Microstructural Transitions in Aqueous Dispersions of Ionic‐Liquids‐Based Surfactants

“…The extent of growth and the micellar dimension mainly depend on the functionality of the head group, nature and concentration of the added counter ions . It is worth mentioning here that several amphiphilic molecules including surfactants,, phospholipids and ILBSs show aggregate transformation from the spherically shaped aggregates to various aggregated structures such as nano‐rods, closed bilayers (vesicles), cubosome, bimembrane and onion‐type vesicles.…”