Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

Dai, Guidong; Li, Benpeng; Xu, Yuping; Li, Zhiji; Mo, Fuchun; Wei, Chaoqian

doi:10.1016/j.ejphar.2021.173869

Cited by 19 publications

(11 citation statements)

References 32 publications

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“…The acetic acid test is a standard pain test and a model for exploring behavioural responses to acetic acid to determine the intensity of pain and also the effect of analgesics or other tested substances [ 32 , 33 ]. This test is generally used in mammals [ 34 , 35 ] but has been applied to other non-mammalian studies investigating fishes, amphibians, and cephalopods (e.g., [ 23 , 35 , 36 ]). Cuttlefish received less attention with respect to nociception and the present study demonstrates that “wound”-directed behaviours do occur in S. pharoaensis .…”

Section: Discussionmentioning

confidence: 99%

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Kuo

Sneddon

Spencer

et al. 2022

Biology

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Nociception is the neural process of encoding noxious stimuli and is typically accompanied by a reflex withdrawal response away from the potentially injurious stimulus. Studies on nociception in cephalopods have so far focused on octopus and squid, with no investigations to our knowledge on cuttlefish. Yet, these are an important species both in scientific and commercial use. Therefore, the present study demonstrated that a standard pain stimulus, acetic acid, induced grooming behaviour directed towards the injection site in cuttlefish and that the injection of lidocaine reduces grooming behaviours in acetic-acid-injected cuttlefish. Wound-directed behaviour demonstrates that the animal is aware of the damage; thus, when subjecting these animals to any painful treatments in the laboratory, researchers should consider alleviating pain by the administration of pain-relieving drugs.

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Section: Discussionmentioning

confidence: 99%

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Kuo

Sneddon

Spencer

et al. 2022

Biology

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“…In this combination, matrine could be considered as the “Jun” and “Chen” drug, while paracetamol also bares the property of “Chen” drug. In practice, it has been reported that there is a synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice ( Dai et al, 2021 ).…”

Section: Direct and Background Efficacy Of Traditional Chinese Medici...mentioning

confidence: 99%

“…Specifically, matrine could generate antinociceptive effects on variety of pain models, including acute pain in tail-flick test (Dosage: 30 mg/kg; Positive control: pentazocine) ( Kamei et al, 1997 ), abdominal pain in acetic acid-induced abdominal contraction test (Dosage: 1, 3, 10 mg/kg; Positive control: pentazocine) ( Kamei et al, 1997 ; Dai et al, 2021 ), and neuropathic pain induced by vincristine (Dosage: 15, 30, 60 mg/kg; Positive control: pregabalin) ( Dun et al, 2014 ) or chronic constriction injury (Dosage: 7.5, 15, 30 mg/kg) ( Wang et al, 2013a ). In China, matrine has been used for clinical conditions of atrophic vaginitis and bacterial vaginitis ( Zhang and Shen, 2021 ), since it can reduce infections, vaginal itching and swelling.…”

Section: Introduction Of Traditional Chinese Medicine Derived Analges...mentioning

confidence: 99%

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management

et al. 2022

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Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine, sinomenine, ligustrazine, evodiamine, brucine, tetrandrine, Stopholidine, and lappaconitine, focusing on their mechanisms and potential clinical applications. To better describe the mechanism of these alkaloids, we adopted the concept of drug-cloud (dCloud) theory. dCloud illustrated the full therapeutic spectrum of multitarget analgesics with two dimensions, which are “direct efficacy”, including inhibition of ion channels, activating γ-Aminobutyric Acid/opioid receptors, to suppress pain signal directly; and “background efficacy”, including reducing neuronal inflammation/oxidative stress, inhibition of glial cell activation, restoring the balance between excitatory and inhibitory neurotransmission, to cure the root causes of chronic pain. Empirical evidence showed drug combination is beneficial to 30–50% chronic pain patients. To promote the discovery of effective analgesic combinations, we introduced an ancient Chinese therapeutic regimen that combines herbal drugs with “Jun”, “Chen”, “Zuo”, and “Shi” properties. In dCloud, “Jun” drug acts directly on the major symptom of the disease; “Chen” drug generates major background effects; “Zuo” drug has salutary and supportive functions; and “Shi” drug facilitates drug delivery to the targeted tissue. Subsequently, using this concept, we interpreted the therapeutic effect of established analgesic compositions containing TCM derived analgesic alkaloids, which may contribute to the establishment of an alternative drug discovery model.

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“…This is a useful model to assess the analgesic potential of candidate compounds (due to amount limitation, the antinociception of 1 was not evaluated). 15 Although not as strong as Z944 (10 mg kg À1 ), a TTCC antagonist under clinical trial for the treatment of pain, 2 at dose of 20 mg kg À1 (p o 0.001) clearly reduced the number of writhes within 30 min after injection of acetic acid (Fig. 4G).…”

mentioning

confidence: 91%

Caged polycyclic polyprenylated acylphloroglucinols as Ca_v3.2 low voltage-gated Ca²⁺ channel inhibitors from Hypericum curvisepalum

Jiang

et al. 2022

Chem. Commun.

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Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

Cited by 19 publications

References 32 publications

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management

Caged polycyclic polyprenylated acylphloroglucinols as Ca_v3.2 low voltage-gated Ca²⁺ channel inhibitors from Hypericum curvisepalum

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Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

Cited by 19 publications

References 32 publications

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Impact of Lidocaine on Pain-Related Grooming in Cuttlefish

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management

Caged polycyclic polyprenylated acylphloroglucinols as Cav3.2 low voltage-gated Ca2+ channel inhibitors from Hypericum curvisepalum

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Caged polycyclic polyprenylated acylphloroglucinols as Ca_v3.2 low voltage-gated Ca²⁺ channel inhibitors from Hypericum curvisepalum