Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells

Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies onEuphorbiaFactor L3Derivatives

“…Nineteen derivatives were found to be superior to verapamil (VRP) in initial screens. From these results, the Group I (4, 6, 7, 10-14), II (19,20,(22)(23)(24)(25)(26)(27) and V (32, 36, 39) derivatives were emphatically observed. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 …”

Euphorbia factor L1 reverses ABCB1‐mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion

“…Qiterpenoids isolated from geunus Euphorbia are the big family containing hundreds of compounds performing various biological activities such as antiproliferation, modulability of MDR, cytotoxic activity, antimicrobial, and antiinflammatory activity Choi et al, 2009]. Recently, evidence proves that some of them can modulate ABCB1 [Duarte et al, 2007;Duarte et al, 2008;Jiao et al, 2009]. Herein EFL1 showed potent ability of reversing ABCB1-mediated MDR (Table I).…”

Macrocyclic Derivatives of Diterpenoid Isosteviol with Hydrazide and Hydrazone Moieties

“…The MALDI spectrum of the product of the reaction of dioxodiester 2 with adipic acid dihydrazide was composed of the main peak group involving the peaks at m/z 801. 6 1 H NMR spectra of the mixtures of macrocycles 4, 6 and 5, 7. Thus three singlets at 10.15, 10.21 and 10.07 ppm were observed in the 1 H NMR spectrum of the mixtures of macrocycles 4 and 6, whereas only two singlets at 10.06 и 9.09 ppm were observed in the 1 H NMR spectrum of the mixture of macrocycles 5 and 7.…”