Synergistic Interaction Between α2-Adrenergic Agonists and Benzodiazepines in Rats

Salonen, Markku; Reid, Kristina; Maze, Mervyn

doi:10.1097/00000542-199206000-00022

Cited by 79 publications

(39 citation statements)

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“…Dexmedetomidine has been shown to have no interaction with GABA-benzodiazepine receptors. 22 Of the 2 patients who did not receive anesthesia, BP ND values were still below the parent and control range. Moreover, tracer delivery, measured by R1, did not differ across the groups.…”

Section: Figure 2 [11c]-flumazenil Pet Scans In An Affected Subject (mentioning

confidence: 91%

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Pearl¹,

Gibson²,

Quezado³

et al. 2009

Neurology

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Objective: Succinic semialdehyde dehydrogenase (SSADH) deficiency is an autosomal recessive disorder of GABA metabolism characterized by elevated levels of GABA and gammahydroxybutyric acid. Clinical findings include intellectual impairment, hypotonia, hyporeflexia, hallucinations, autistic behaviors, and seizures. Autoradiographic labeling and slice electrophysiology studies in the murine model demonstrate use-dependent downregulation of GABA(A) receptors. We studied GABA(A) receptor activity in human SSADH deficiency utiliz- Succinic semialdehyde dehydrogenase (SSADH) deficiency, also called 4-hydroxybutyric aciduria (McKusick 279180) and aldehyde dehydrogenase 5a1 (Aldh5a1), is an autosomal recessive disorder. About 350 patients are known, with about 85% under 18, making this the most prevalent pediatric neurotransmitter disorder. 1 In the absence of SSADH, transamination of GABA to succinic semialdehyde is followed by its conversion to 4-hydroxybutryic acid (gamma-hydroxybutyric acid, or GHB), leading to CNS GABA and ␥-hydroxy butyrate (GHB) accumulation.2 Major clinical manifestations include developmental delay, hypotonia, ataxia, and seizures. Hyperkinetic behavior, aggression, self-injurious behaviors, and hallucinations have also been described; EEG abnormalities include generalized and focal epileptiform discharges, photosensitivity, and background slowing.

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Section: Figure 2 [11c]-flumazenil Pet Scans In An Affected Subject (mentioning

confidence: 91%

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Pearl¹,

Gibson²,

Quezado³

et al. 2009

Neurology

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show abstract

“…Com a associação , há um sinergismo (SALONEN et al, 1992). HORVATH et al (1992) verificaram em uma associação com dexmedetomidina e diazepam que, em ambos os fármacos, menos de um quarto de suas doses isoladas, eram necessários para produzir o mesmo efeito, confirmando assim, um sinergismo capaz de produzir uma hipnose maior pela ação da dexmedetomidina e o diazepam.…”

Section: Resultsunclassified

Parametria da associação do midazolam ou diazepam em cães pré-tratados pela atropina e tratados pela dexmedetomidina e quetamina

et al. 2006

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“…The administration of antagonists of either class of drug does not reverse the effects of the other, i.e. atipamezole and flumazenil [101]. The duration of the hypnotic action of dexmedetomidine was increased by the administration of verapamil, a calcium channel blocker, the reverse effect was seen with the administration of a calcium antagonist [102].…”

Section: Drug and Receptor Interactionsmentioning

confidence: 96%

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

Khan¹,

Ferguson²,

Jones³

1999

Anaesthesia

606

423

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SummaryClonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have a role in providing haemodynamic stability in patients who are at risk of peri-operative ischaemia. The side-effects of hypotension and bradycardia have limited the routine use of alpha-2 adrenoceptor agonists. Investigations into the molecular pharmacology of alpha-2 adrenoceptors have elucidated their role in the control of wakefulness, blood pressure and antinociception. We discuss the pharmacology of alpha-2 adrenoceptors and their therapeutic role in this review.

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Synergistic Interaction Between α2-Adrenergic Agonists and Benzodiazepines in Rats

Cited by 79 publications

References 0 publications

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Parametria da associação do midazolam ou diazepam em cães pré-tratados pela atropina e tratados pela dexmedetomidina e quetamina

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

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