Synergistic size and charge conversions of functionalized PAMAM dendrimers under the acidic tumor microenvironment

Liao, Zaiyi; Hu, Shumin; Zhang, Leitao; Wu, Wen-Lan; Cheng, Qiuli; Li, Junbo; Narain, Ravin

doi:10.1039/d2bm00643j

Cited by 5 publications

(11 citation statements)

References 40 publications

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“…Characterization of G4-AB/CuS. First, the surface of G4 was modified by zwitterionic monomer AB, 6 and G4-AB was obtained, which was determined by 1 H NMR and FTIR, as shown in Figures S1 and S2. The CuS nanoparticles were synthesized in the inner hydrophobic cavity of G4-AB through in situ vulcanization of the nanocomplexes G4-AB with Cu (II).…”

Section: Resultsmentioning

confidence: 99%

Codelivery of CuS and DOX into Deep Tumors with Size and Charge-Switchable PAMAM Dendrimers for Chemo–photothermal Therapy

Hu,

Zhang,

Cheng

et al. 2023

ACS Appl. Mater. Interfaces

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Accurate targeting of therapeutic agents to specific tumor tissues, especially via deep tumor penetration, has been an effective strategy in cancer treatments. Here, we described a flexible nanoplatform, pH-responsive zwitterionic acylsulfonamide betaine-functionalized fourth-generation PAMAM dendrimers (G4-AB), which presented multiple advantages for chemo–photothermal therapy, including template synthesis of ultrasmall copper sulfide (CuS) nanoparticles and further encapsulation of doxorubicin (DOX) (G4-AB-DOX/CuS), long-circulating performance by a relatively large size and zwitterionic surface in a physiological environment, combined size shrinkage, and charge conversions via pH-responsive behavior in an acidic tumor microenvironment (TME). Accordingly, high tumor penetration and positive cell uptake for CuS and DOX have been determined, which triggered an excellent combination treatment under near-infrared irradiation in comparison to the monochemotherapy system and irresponsive chemo–photothermal system. Our study represented great promise in constructing multifunctional carriers for the effective delivery of photothermal nanoparticles and drugs in chemo–photothermal therapy.

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Section: Resultsmentioning

confidence: 99%

Codelivery of CuS and DOX into Deep Tumors with Size and Charge-Switchable PAMAM Dendrimers for Chemo–photothermal Therapy

Hu,

Zhang,

Cheng

et al. 2023

ACS Appl. Mater. Interfaces

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“…Owing to the unique monomolecular structure, unimolecular micelles can maintain high stability when facing special environmental changes such as sharp dilution, pH reduction, and large changes in ionic strength (Figure 7C). [74,75] Whereas traditional polymeric micelles might disintegrate under these environment changes. The development of unimolecular micelles greatly improves the in vivo stability of micellar drug delivery systems, which further prevents the unexpected drug leakage.…”

Section: Self-assembly Of Dendrimersmentioning

confidence: 99%

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Wang,

Zhang,

et al. 2023

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Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for delivering anticancer agents due to the explicit study of their characteristics of particle size, charge, and biological properties such as toxicity, blood circulation time, biodistribution, and cellular internalization. Here, the classification, preparation, and structure of dendrimer micelles are reviewed, and the specific functional groups modified on the surface of dendrimers for tumor active targeting, stimuli‐responsive drug release, reduced toxicity, and prolonged blood circulation time are discussed. In addition, their applications are summarized as various platforms for biomedical applications related to cancer therapy including drug delivery, gene transfection, nano‐contrast for imaging, and combined therapy. Other applications such as tissue engineering and biosensor are also involved. Finally, the possible challenges and perspectives of dendrimer micelles for their further applications are discussed.

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“…[27][28][29] This leads to the generation of electrostatic repulsive forces in the copolymer networks that induce pH-dependent swelling and deswelling in the porous hydrogel network as the water is either absorbed or expelled. 19,[30][31][32] Owing to these unique characteristic features, hydrogels have been used in various fields of medicine, including oncology, immunology, cardiology and wound healing. The presence of a large volume of water in the hydrogel network provides structural similarity to biological tissues as the network is typically soft with a Young's modulus of 1 kPa to 1 MPa.…”

Section: Thavasyappan Thambimentioning

confidence: 99%

Recent strategies to develop pH-sensitive injectable hydrogels

2023

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Synergistic size and charge conversions of functionalized PAMAM dendrimers under the acidic tumor microenvironment

Abstract: Developing nanomedicine with highly adaptive behaviors has presented great effectiveness in cancer treatment. However, the multi-functional integration of nano-therapeutic system inevitably leads to the complexity in structure and impairs the...

Cited by 5 publications

References 40 publications

Codelivery of CuS and DOX into Deep Tumors with Size and Charge-Switchable PAMAM Dendrimers for Chemo–photothermal Therapy

Codelivery of CuS and DOX into Deep Tumors with Size and Charge-Switchable PAMAM Dendrimers for Chemo–photothermal Therapy

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Recent strategies to develop pH-sensitive injectable hydrogels

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