2024
DOI: 10.1002/adma.202401111
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Synergizing Pyroelectric Catalysis and Enzyme Catalysis: Establishing a Reciprocal and Synergistic Model to Enhance Anti‐Tumor Activity

Yan Wang,
Rui Zhang,
Pengyu Zang
et al.

Abstract: Nanozyme activity is greatly weakened by the microenvironments and multidrug resistance of tumor cells. Hence, we developed a bi‐catalytic nanoplatform, which promotes the anti‐tumor activity through “charging empowerment” and “mutual complementation” processes involved in enzymatic and pyroelectric catalysis, by loading ultra‐small nanoparticles (USNPs) of pyroelectric ZnSnO3 onto MXene nanozyme (V2CTx nanosheets). Here, the V2CTx nanosheets exhibit enhanced peroxidase activity by reacting V3+ with H2O2 to ge… Show more

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