Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine: Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer

Shariati, Molood; Lollo, Giovanna; Matha, Kevin; Descamps, Benedicte; Vanhove, Christian; Sande, Leen Van de; Willaert, Wouter; Balcaen, Lieve; Vanhaecke, Frank; Benoit, Jean‐Pierre; Ceelen, Wim; Smedt, Stefaan C. De

doi:10.1021/acsami.0c05554

Cited by 29 publications

(43 citation statements)

References 62 publications

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“…The main finding of our study is that both a positive charge and the electrostatic precipitation increase the depth of tissue penetration of CUR-PLGA-NPs. Our results are in line with prior data [13,27].…”

Section: Discussionsupporting

confidence: 92%

“…Aerosolization of cisplatin-loaded polyargininehyaluronic acid nanoscale particles (Cis-pARG-HA NPs) using PIPAC efficiently eradicated peritoneal metastasis in a rat model of human ovarian cancer. At the same time, this effect was not observed for the administration of free cisplatin [27].…”

Section: Discussionmentioning

confidence: 85%

“…A combination of PIPAC with nanoparticles might further improve the target effect of the drug in the peritoneal tissue. The efficacy of this combined approach has recently been proven in an animal model of disseminated peritoneal ovarian tumors, where PIPAC enhanced intratumoral deposition of fluorescent pARG-HA nanoparticles [27]. It has also been suggested that adding electrostatic loading and following precipitation of the therapeutic aerosol might optimize tissue effects of PIPAC [22].…”

Section: Discussionmentioning

confidence: 99%

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Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Castagna

Zander

Sautkin

et al. 2021

Nanomedicine (Lond.)

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Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. Conclusion: The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Castagna

Zander

Sautkin

et al. 2021

Nanomedicine (Lond.)

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“…For example, one recent study demonstrated synergistic effects similar to those observed in this study with combination cisplatin-hyaluronic acid treatment in advanced metastatic ovarian cancer [19]. Another study also found that combination therapy involving hyaluronic acid exhibited synergistic and enhanced anti-tumor effects among aggressive breast cancers [20].…”

Section: Discussionsupporting

confidence: 82%

Evaluation of Hyaluronic Acid to Modulate Oral Squamous Cell Carcinoma Growth In Vitro

Ringer

Morrison

Kingsley

2020

JFB

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Introduction: Previous studies have demonstrated that glycosaminoglycan hyaluronic acid (HA) is capable of mediating oral tumor growth. Some clinical evidence has suggested reduced HA expression predicts poor cancer prognosis and that HA-chemotherapy conjugates may function synergistically to inhibit oral tumor growth. Other studies have found conflicting results that suggest enhanced CD44-HA-mediated growth and proliferation. Due to the lack of clarity regarding HA function, the primary goal of this study was to investigate the effects of HA using well-characterized oral cancer cell lines. Methods: Using several commercially available oral squamous cell carcinoma lines (and a normal non-cancerous control), 96-well growth and viability assays were conducted using HA (alone and in combination with chemotherapeutic agents paclitaxel and PD98059). Results: Different results were observed in each of the cell lines evaluated. HA induced small, non-significant changes in cellular viability among each of the cell lines within a narrow range (1–8%), p = 0.207. However, HA induced differing effects on growth, with minimal, non-significant changes among some cell lines, such as SCC4 (+1.7%), CCL-30 (−2.8%), and SCC15 (−2.5%), p = 0.211 and more robust inhibition among other cell lines, SCC9 (−24.4%), SCC25 (−36.6%), and CAL27 (−47.8%), p = 0.0001. Differing effects were also observed with growth and viability under concomitant administration of HA with PD98059 or paclitaxel. Further analysis of these data revealed strong inverse (Pearson’s) correlations between initial baseline growth rate and responsiveness to HA administration, ranging from R = −0.27 to R = −0.883. Conclusion: The results of this study revealed differing responses to HA, which may be inversely correlated with intrinsic characteristics, such as the baseline growth rate. This may suggest that the more rapidly growing cell lines are more responsive to combination therapy with hyaluronic acid; an important finding that may provide insights into the mechanisms responsible for these observations.

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“…Experimental data suggest that formulations with prolonged intraperitoneal release administered as thermosensitive hydrogels or gelatin microspheres result in sustained (up to 14 days) exposure of residual peritoneal disease, whereas they simultaneously may prohibit formation of adhesion postoperatively [96,97]. Others have developed cisplatin-loaded polyarginine-hyaluronic acid nanoscale particles, which demonstrated increased anti-tumour efficacy when compared with free cisplatin after intraperitoneal administration in a rat model [98]. This development of new drug formulations may further improve the efficacy of HIPEC for peritoneal malignancies, such as advanced ovarian cancer, in the future.…”

Section: New Drug Formulationsmentioning

confidence: 99%

Pharmacological considerations regarding intraoperative hyperthermic intraperitoneal chemotherapy for ovarian cancer

2021

EJGO

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Since ovarian cancer is limited to the peritoneal cavity for a prolonged period during the disease course, intraperitoneal chemotherapy seems a rational treatment option for residual peritoneal disease after cytoreductive surgery. Intraperitoneal when compared with intravenous chemotherapy exhibits a clear pharmacokinetic benefit. Performing intraperitoneal chemotherapy under hyperthermic conditions, as in intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC), may enhance its therapeutic efficacy. Herein, the pharmacological aspects of (hyperthermic) intraperitoneal chemotherapy are discussed, including pharmacokinetics, drug penetration depth into the tumour, drug characteristics, optimal drug choice and the role of hyperthermia. Further clinical pharmacological studies are needed to appraise the optimal drug regimen for HIPEC in patients with primary and recurrent ovarian cancer. Development of new drugs and drug formulations may further improve the efficacy of HIPEC in the future.

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Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine: Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer

Cited by 29 publications

References 62 publications

Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Evaluation of Hyaluronic Acid to Modulate Oral Squamous Cell Carcinoma Growth In Vitro

Pharmacological considerations regarding intraoperative hyperthermic intraperitoneal chemotherapy for ovarian cancer

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