Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

L.A., Chang,; Shan, Jing; Hou, Xinxin; Li, Da‐Jin; Wang, Xiaoqiu

doi:10.1016/j.jri.2023.103975

Cited by 8 publications

(3 citation statements)

References 111 publications

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“…The observed downregulation of T cell-related genes such as CD3e, CD3g, GATA3, and CTLA4 is consistent with the diminished CD3+ T cell populations and highlights the relevance of CNR2 in T cellmediated immune responses within the endometriotic microenvironment. KEGG pathway analysis of differentially expressed immune-related genes in CNR2 k/o DD lesions further revealed that Th1, Th2, and Th17 cell differentiation pathways were impacted, and the previous literature confirms dysregulation of these pathways in EM pathophysiology 43,44 . Additionally, our in-vitro functional assay showing CD4+ helper T cells being affected (proliferation) more than the CD8+ cytotoxic T cell subset further adds to the subset specific behaviour of CNR2.…”

Section: Discussionsupporting

confidence: 54%

“…KEGG pathway analysis of differentially expressed immune-related genes in CNR2 k/o DD lesions further revealed that Th1, Th2, and Th17 cell differentiation pathways were impacted, and the previous literature confirms dysregulation of these pathways in EM pathophysiology 41,42 . Additionally, our in-vitro functional assay showing CD4+ helper T cells being affected (proliferation) more than the CD8+ cytotoxic T cell subset further adds to the subset specific behaviour of CNR2.…”

Section: Discussionsupporting

confidence: 53%

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Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

Lingegowda,

Zutautas,

Wei

et al. 2023

Preprint

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Endometriosis (EM), characterized by the presence of endometrial-like tissue outside the uterus, is the leading cause of chronic pelvic pain and infertility in females of reproductive age. Despite its high prevalence, the molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) is known to influence several cardinal features of this complex disease including pain, vascularization, and overall lesion survival, but the exact mechanisms are not known. Utilizing CNR1 knockout (k/o), CNR2 k/o and wild type (WT) mouse models of EM, we reveal contributions of ECS and these receptors in disease initiation, progression, and immune modulation. Particularly, we identified EM-specific T cell dysfunction in the CNR2 k/o mouse model of EM. We also demonstrate the impact of decidualization-induced changes on ECS components, and the unique disease-associated transcriptional landscape of ECS components in EM. Imaging Mass Cytometry (IMC) analysis revealed distinct features of the microenvironment between CNR1, CNR2, and WT genotypes in the presence or absence of decidualization. This study, for the first time provides an in-depth analysis of the involvement of the ECS in EM pathogenesis and lays the foundation for the development of novel therapeutic interventions to alleviate the burden of this debilitating condition.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionsupporting

confidence: 53%

Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

Lingegowda,

Zutautas,

Wei

et al. 2023

Preprint

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“…In the context of endometriosis, there is a notable reduction in the Th1/Th2 cell ratio within the peritoneal fluid (PF) when compared to women with a healthy condition[ 105 ]. This shift is accompanied by increased concentrations of IFN-γ and IL-10, resulting in elevated IL-4/IFN-γ, IL-4/IL-2, IL-10/IFN-γ, and IL-10/IL-2 ratios within endometriotic lesions[ 106 ].…”

Section: Immune Dysregulation In Endometriosis and Estrogen Dependenc...mentioning

confidence: 99%

Immune pathway through endometriosis to ovarian cancer

Calmon,

Lemos,

Silva Luz

et al. 2024

World J Clin Oncol

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Endometriosis is an estrogen-dependent inflammatory disease, defined by the presence of functional endometrial tissue outside of the uterine cavity. This disease is one of the main gynecological diseases, affecting around 10%-15% women and girls of reproductive age, being a common gynecologic disorder. Although endometriosis is a benign disease, it shares several characteristics with invasive cancer. Studies support that it has been linked with an increased chance of developing endometrial ovarian cancer, representing an earlier stage of neoplastic processes. This is particularly true for women with clear cell carcinoma, low-grade serous carcinoma and endometrioid. However, the carcinogenic pathways between both pathologies remain poorly understood. Current studies suggest a connection between endometriosis and endometriosis-associated ovarian cancers (EAOCs) via pathways associated with oxidative stress, inflammation, and hyperestrogenism. This article aims to review current data on the molecular events linked to the development of EAOCs from endometriosis, specifically focusing on the complex relationship between the immune response to endometriosis and cancer, including the molecular mechanisms and their ramifications. Examining recent developments in immunotherapy and their potential to boost the effectiveness of future treatments.

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The correlation between immune cells and endometriosis: a bidirectional two-sample mendelian randomization study

Pan,

Chen,

Zhou

et al. 2024

BMC Women's Health

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Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

Cited by 8 publications

References 111 publications

Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

Immune pathway through endometriosis to ovarian cancer

The correlation between immune cells and endometriosis: a bidirectional two-sample mendelian randomization study

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