Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells

Tu, Zhengkun; Hamalainen-Laanaya, Heli K.; Crispe, Ian Nicholas; Orloff, Mark S.

doi:10.1016/j.cellimm.2011.07.006

Cited by 17 publications

(19 citation statements)

References 32 publications

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“…4B, 5). These results are consistent with data obtained in previous studies (Tu et al, 2011). The significant enhancement of IFN-g secretion in NK cells after NDV stimulation (Fig.…”

Section: Discussionsupporting

confidence: 83%

TRAIL is Involved in the Tumoricidal Activity of Mouse Natural Killer Cells Stimulated by Newcastle Disease Virus in Vitro

Song

Liang

Xiao

et al. 2013

The Anatomical Record

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Newcastle disease virus (NDV) is a potential antitumor agent, and its antitumor effect has been evaluated in preclinical tests. However, the mechanisms of NDV-based antitumor therapy are still not completely clear. In the present study we found that NDV-stimulation enhanced the killing ability of mouse spleen natural killer (NK) cells towards mouse hepatoma cell lines, and tumor necrosis factor (TNF)-related apoptosisinducing ligand (TRAIL) plays an important role in this tumoricidal activity. NDV stimulation induced up-regulation of TRAIL both at the mRNA and protein levels in NK cells. Blocking TRAIL by antibody (Ab) almost completely eliminated the killing effect of NK cells on hepatoma cell lines.

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“…4B, 5). These results are consistent with data obtained in previous studies (Tu et al, 2011). The significant enhancement of IFN-g secretion in NK cells after NDV stimulation (Fig.…”

Section: Discussionsupporting

confidence: 83%

TRAIL is Involved in the Tumoricidal Activity of Mouse Natural Killer Cells Stimulated by Newcastle Disease Virus in Vitro

Song

Liang

Xiao

et al. 2013

The Anatomical Record

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“…4B) can also induce NK activity (37). Activated DCs and KCs secrete IL-6, IL-12, and TNF-␣, which stimulate NK (38,39) and NKT (40) cells to produce IFN-␥. In turn, IFN-␥ upregulates NKmediated lysis of HBV-infected cells, enhances the cytokine response of KC, and recruits HBV-specific T cells (41).…”

Section: Discussionmentioning

confidence: 99%

Poly(I:C) Treatment Leads to Interferon-Dependent Clearance of Hepatitis B Virus in a Hydrodynamic Injection Mouse Model

Huang

Zhao

et al. 2014

J Virol

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“…STAT1 and IRF1 are thought to directly mediate the effects of IFN-γ on the TRAIL promoter. IFN-γ has also been shown to induce FasL- and TRAIL-dependent apoptosis in lung cancer cells 53 and is responsible for IL18- and TLR3-induced TRAIL expression in NK cells 54 …”

Section: Regulation Of the Human Trail Genementioning

confidence: 99%

Regulation of the human TRAIL gene

Allen

El‐Deiry

2012

Cancer Biology & Therapy

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TRAIL is a member of the TNF superfamily that induces tumor-selective cell death by engaging the pro-apoptotic death receptors DR4 and DR5. The antitumor potential of the TRAIL pathway has been targeted by several therapeutic approaches including recombinant TRAIL and TRAIL-receptor agonist antibodies among others. Interest in sensitizing tumor cells to TRAIL-mediated apoptosis has driven investigations of TRAIL-receptor gene regulation, though regulation of the TRAIL gene has been less studied. Physiologically, TRAIL serves as a pro-apoptotic effector molecule in the immune surveillance of cancer that is conditionally expressed by immune cells upon stimulation via an interferon-response element that was identified in early studies of the TRAIL gene promoter. Here, we map the TRAIL gene promoter and review studies of TRAIL gene regulation that involve several modalities of gene regulation including transcription factors, epigenetics, single-nucleotide polymorphisms and functionally distinct isoforms.

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Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells

Cited by 17 publications

References 32 publications

TRAIL is Involved in the Tumoricidal Activity of Mouse Natural Killer Cells Stimulated by Newcastle Disease Virus in Vitro

TRAIL is Involved in the Tumoricidal Activity of Mouse Natural Killer Cells Stimulated by Newcastle Disease Virus in Vitro

Poly(I:C) Treatment Leads to Interferon-Dependent Clearance of Hepatitis B Virus in a Hydrodynamic Injection Mouse Model

Regulation of the human TRAIL gene

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