Synovial Fluid Lubrication: The Effect of Protein Interactions on Adsorbed and Lubricating Films

Parkes, Maria; Myant, Connor; Cann, P. M.; Wong, Janet S.S.

doi:10.1016/j.biotri.2015.05.001

Cited by 34 publications

(27 citation statements)

References 56 publications

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“…Most likely, the secondary structures of SF proteins and tropocollagen are affected in OA . Most of the studies found are concerned with adsorption and desorption of proteins in different kinematic conditions and film thickness in different pH, buffer, and concentration of proteins . Frictional coefficients, frictional force, shear force, wear measurement, boundary lubrication, surface geometry, rheology of various constituents are also considered in connection with proteins and other SF components to explore the knowledge in this area .…”

Section: Discussionmentioning

confidence: 99%

“…In the case of mixed proteins, the ability of BGG to form thick layers was decreased. Therefore, the interaction between the proteins influences the process of film formation …”

Section: Biochemical and Mechanical Properties Of Sf And Joint Replacmentioning

confidence: 99%

“…Parkes et al also stated that under the rolling condition, protein layers are much thicker compared with statically adsorbed layers. From the study of Fan et al, it was also found that much thicker films were formed in case of γ‐globulin occurrence, although by monolayer or multilayer adsorbed protein forms a thin residual film.…”

Section: Biochemical and Mechanical Properties Of Sf And Joint Replacmentioning

confidence: 99%

“…Therefore, the interaction between the proteins influences the process of film formation. 13 At physiological pH, the films are formed by large irregular deposits in solutions. However, both the protein adsorption kinetics and the formation of tribofilms are influenced by the solution pH, whether statically or under the rolling conditions.…”

Section: Ph Dependency Of Protein Film Formationmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review on correlation between biochemical and mechanical processes of lubricant film formation in joint replacement of the last 10 years

Rufaqua

Vrbka

Choudhury

et al. 2019

Lubrication Science

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This study provides a systematic review of the synovial and simulated body fluid research for the last 10 years (2006 to 2016). In particular, biochemical and mechanical properties of synovial fluid after joint replacement are focused, namely, the chemical composition of the formed lubricating film and structural changes of the associated proteins under mechanical loading. In summary, the formation of the film depends on pH, viscosity, and concentration of the solution, static, sliding, and rolling conditions and other factors related to the joint replacement. However, chemical changes of the synovial fluid proteins after the joint replacement are rarely addressed and require further attention. To this end, we provide a preliminary study of selected proteins within the synovial fluid using Raman spectroscopy. We conclude that chemical analysis together with the analysis of mechanical and biological properties of the synovial fluid after total joint replacement will help in comprehension of the process.

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Section: Discussionmentioning

confidence: 99%

“…In the case of mixed proteins, the ability of BGG to form thick layers was decreased. Therefore, the interaction between the proteins influences the process of film formation …”

Section: Biochemical and Mechanical Properties Of Sf And Joint Replacmentioning

confidence: 99%

Section: Biochemical and Mechanical Properties Of Sf And Joint Replacmentioning

confidence: 99%

Section: Ph Dependency Of Protein Film Formationmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review on correlation between biochemical and mechanical processes of lubricant film formation in joint replacement of the last 10 years

Rufaqua

Vrbka

Choudhury

et al. 2019

Lubrication Science

View full text Add to dashboard Cite

show abstract

“…The λ-values are derived by classical theory, which may not accurately describe the system. It has been shown by [27,28,60,61] that with proteins a gel-type lubrication is more likely. Thus, the calculated λ-values may interpret the contact situation incorrectly, which could be more within the mixed regime.…”

Section: Limitationsmentioning

confidence: 99%

On the Growth Rate of Tribomaterial in Bovine Serum Lubricated Sliding Contacts

et al. 2016

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Considering total hip arthroplasty, so-called tribolayers (aka tribomaterial), consist of carbonaceous material from the periprosthetic joint fluid or bovine serum mixed with nanometer size metal and oxide wear particles. Currently, its growth sequence and rate are unknown. Thus, smooth surfaces of low-Carbon (LC-) vs. high-Carbon (HC-)CoCrMo (Cobalt-Chromium-Molybdenum) alloys have been worn in a conforming contact under bovine serum lubrication by means of a pin-on-ball wear tester. These tests were interrupted at certain numbers of cycles in order to weigh the specimens, characterize the topography, and investigate the wear appearances. In addition, after cleaning in ethanol and anionic detergent, before-and-after comparison rendered the weight of the tribomaterial. This revealed that, during run-in, the specimens gained weight by generating tribomaterial. Afterwards the loss of material surpassed the generation of new tribomaterial and a steady weight-loss was measured. Topography measurements were used as input data for contact mechanics calculations. Apparently the incipient, locally high contact stresses accelerated tribochemical reactions. After run-in, the contact situation changes and leads to a much smaller generation rate. This paper provides information about the growth sequence and rate of such tribomaterial formation. It further highlights the significance of highly localized contact stress as an important factor for tribomaterial generation.

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Engineering a ceramic piston pump to minimize particle formation for a therapeutic immunoglobulin: A combined factorial and modeling approach

Roffi

Sebastião

Morel

2022

J Adv Manuf & Process

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During fill-finish manufacturing, protein-pump surface interactions can induce subvisible particle (SVP) formation which poses a risk to drug product quality and patient safety. Despite this risk, there have been no concerted efforts to understand the effects of piston pump design on SVP formation.We've systematically varied the design of the piston-cylinder interface to minimize SVP formation for a therapeutic immunoglobulin. The clearance factor, surface roughness factor, and their combined interaction significantly affected particle concentrations, quantitated by light obscuration and microflow imaging. Optimized pump designs reduced particle levels by 1-2 orders of magnitude compared to the off-the-shelf equipment. At the piston surface, scanning electron microscopy revealed evidence of protein film abrasion, a process which ejects SVPs from the piston-cylinder interface as wear debris. Computational fluid dynamics and quartz crystal microbalance were applied to simulate fluid flow and protein adsorption phenomena in the pump respectively. The risk of protein film abrasion was modeled along a hypothetical Stribeck curve, thereby interconnecting design parameters, lubrication conditions, and SVP formation. Our findings support implementation of a modular pump platform with interchangeable pistons; this approach would enable the pump design to be customized based on each protein's propensity to form SVPs. This flexible approach can benefit pharmaceutical manufacturers and patients alike by accelerating tech transfer and improving process control.

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Synovial Fluid Lubrication: The Effect of Protein Interactions on Adsorbed and Lubricating Films

Cited by 34 publications

References 56 publications

A systematic review on correlation between biochemical and mechanical processes of lubricant film formation in joint replacement of the last 10 years

A systematic review on correlation between biochemical and mechanical processes of lubricant film formation in joint replacement of the last 10 years

On the Growth Rate of Tribomaterial in Bovine Serum Lubricated Sliding Contacts

Engineering a ceramic piston pump to minimize particle formation for a therapeutic immunoglobulin: A combined factorial and modeling approach

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