Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway

Qiu, Mingjun; Xie, Yanhua; Tan, Guanghua; Wang, Xiaoxu; Huang, Peiguan; Hong, Liang

doi:10.1016/j.heliyon.2024.e24042

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Qian et al [ 7 ] found that exosomal miR-26b-5p can transform pro-inflammatory M1 macrophages into anti-inflammatory M2 types by targeting the toll-like receptor 3 signaling pathway to alleviate OA. Additionally, Qiu et al [ 8 ] found that exosomal miR-485-3p can alleviate cartilage damage in OA by targeting the NRP1-mediated PI3K/Akt pathway. Furthermore, researchers integrated the less commonly used miR-29a into exosomes, presenting a new approach for treating OA.…”

Section: Mscs In Osteoarthritismentioning

confidence: 99%

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

Pei,

Zhang,

Wang

et al. 2024

World J Stem Cells

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Recently, we read an article published by the Yang et al . The results of this study indicated that engineered exosomes loaded with microRNA-29a (miR-29a) alleviate knee inflammation and maintain extracellular matrix stability in Sprague Dawley rats. The study’s results provide useful information for treating knee osteoarthritis (KOA). This letter, shares our perspectives on treating KOA using engineered exosomes for miR-29a.

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Section: Mscs In Osteoarthritismentioning

confidence: 99%

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

Pei,

Zhang,

Wang

et al. 2024

World J Stem Cells

View full text Add to dashboard Cite

show abstract

An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain

Shipman,

Fonseca,

Dominguez

et al. 2024

Curr Pain Headache Rep

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Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes

Yu,

Xiao,

Guan

et al. 2024

Front. Med.

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Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, and various other contributing factors. The complex interplay of cartilage damage, loss, and impaired repair mechanisms remains a critical and formidable aspect of OA pathogenesis. At the genetic level, multiple genes have been implicated in the modulation of chondrocyte metabolism, displaying both promotive and inhibitory roles. Recent research has increasingly focused on the influence of non-coding RNAs in the regulation of distinct cell types within bone tissue in OA. In particular, an expanding body of evidence highlights the regulatory roles of microRNAs in OA chondrocytes. This review aims to consolidate the most relevant microRNAs associated with OA chondrocytes, as identified in recent studies, and to elucidate their involvement in chondrocyte metabolic processes and ferroptosis. Furthermore, this study explores the complex regulatory interactions between long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in OA, with an emphasis on microRNA-mediated mechanisms. Finally, critical gaps in the current research are identified, offering strategic insights to advance the understanding of OA pathophysiology and guide therapeutic developments in this field.

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Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway

Cited by 4 publications

References 30 publications

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes

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