Synovial Sarcoma of the Head and Neck

Krugman, Mark E.; Rosin, H.; Toker, Cyril

doi:10.1001/archotol.1973.00780020057014

Cited by 24 publications

(6 citation statements)

References 6 publications

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“…Synovial sarcoma (SS) accounts for approximately 2.5-10% of STSs (2). SS is mainly reported to occur in the soft tissues near the joints of the lower and upper limbs, especially the knee joint (3,4) and in the head and neck (5), but rarely in the intrathoracic cavity. SS accounts for 14.7% of all primary intrathoracic sarcomas in the lung, pleura and mediastinum and is also the most common type of primary intrathoracic sarcoma (6).…”

Section: Introductionmentioning

confidence: 99%

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

Yang

Peng

et al. 2021

J Thorac Dis

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Background: Synovial sarcoma (SS) is a rare malignant soft tissue tumor. Primary intrathoracic SS is extremely rare, with limited diagnosis and treatment experiences. The aim of our study was to retrospectively study the clinicopathological characteristics, treatment and prognosis of primary intrathoracic SS and the impact of multidisciplinary team (MDT) management in diagnosis and treatment on patient prognosis. Methods: The clinical and pathological characteristics, treatment, survival and prognosis of patients with primary intrathoracic SS admitted to the National Cancer Center from January 1999 to December 2018, as well as MDT intervention during diagnosis and treatment, were retrospectively analyzed. Results: Thirteen patients were enrolled, including 7 (53.8%) males and 6 (46.3%) females, with primary intrathoracic SS in the lung (8/13, 61.5%), mediastinum (4/13, 30.8%) and pleura (1/13, 7.7%) as confirmed by morphological observation, immunohistochemical (IHC) staining and fluorescence in situ hybridization (FISH). Overall, 10/13 (76.9%) patients underwent surgery, and 6/10 (60.0%) received postoperative adjuvant therapy. Only 23.1% of patients received nonsurgical therapy. The MDT discussed and managed seven patients before and/or after surgery and one patient who did not undergo surgery. The estimated 3and 5-year overall survival (OS) rates were 50.0% and 30.0%, respectively. Patients who were managed by an MDT had a longer median OS time than those who were not (46.0 vs. 18.0 months). Age (P=0.018), tumor location (P=0.029), and Ki-67 (P=0.020) were found to be significantly related to OS.Conclusions: Monophasic morphology and fusion gene characteristics are the main features for the diagnosis of primary intrathoracic SS. MDT management can help obtain accurate diagnoses and provide reasonable therapeutic options.

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Section: Introductionmentioning

confidence: 99%

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

Yang

Peng

et al. 2021

J Thorac Dis

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“…6 Cervical synovial sarcoma has been reported in only 15 patients. Krugman termined in 9 of 10 cases1,2,4J'J1-13J7 reviewed by Krugman et al, 9 and in 1 case reported by Stout.18 None of these was associated with any major vascular structure. No electron-microscopic studies in cervical synovial sarcoma have been reported.…”

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confidence: 94%

Cervical synovial sarcoma at the bifurcation of the carotid artery

Golomb

Górny

Powell

et al. 1975

Cancer

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Cervical synovial sarcoma has been reported in only 15 cases; in none of these was there any association with a vascular structure. A patient with cervical synovial sarcoma encompassing the bifurcation of the left carotid artery underwent a left radical neck dissection, including excision of the left external carotid artery and the hypoglossal nerve. The tumor was dissected away from the common carotid and internal carotid arteries. Although the fibrous pseudo‐capsule of the tumor was focally infiltrated by malignant cells it appeared that the tumor had not involved the fibrous adventitia of the carotid arteries. Radiation therapy with 6000 rads tumor dose was administered to a wide local field. There is no evidence of recurrence 1 year postoperatively. Histologic and ultrastructural findings were similar to those reported previously in a case of synovial sarcoma of an extremity.

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“…A similar distribution is found in synovial sarcomata of the hypopharynx. The average age at diagnosis of 16 cases (Roth etal., 1975;Palmer etal., 1983;Gatti etal., 1975;Krugman etal., 1973; and the present case) was 30.9 years (ranging from 12 to 62, with 75 per cent under 40 years old). The most typical presentation of synovial sarcoma is of a mass, associated with pain in about 40-60 per cent of cases (Pack and Ariel, 1950;Enzinger and Weiss, 1983).…”

Section: Discussionmentioning

confidence: 99%