Synovial Sarcoma Oropharynx - A Case Report and Review of Literature

Primary Synovial Sarcoma of the Pharynx: A Series of Five Cases and Literature Review

“…The fact that all five of our cases were biphasic is interesting because monophasic SS usually outnumbers biphasic SS elsewhere in the body. However, single case reports describing SS of the pharynx provide mixed evidence with some showing biphasic and others showing monophasic histological pattern [1,6,[16][17][18][19]. We suggest that there may be some as yet unreported association between SS of the pharynx and biphasic histological pattern.…”

“…Since the first case of primary hypopharyngeal SS reported by Jernstorm [5], several independent case reports have been published. However, there are very few case series of primary SS of the pharynx in English literature [1]. In spite of extensive review of the literature, we could not find case series focusing exclusively on pharyngeal SS.…”

“…Synovial sarcoma is a translocation associated malignant neoplasm mainly affecting young adults with a propensity to occur in extremities (particularly the knee) followed by the head and neck region, the latter accounting for 5-10 % of all cases [1,3,4]. Head and neck SS usually arise in the paravertebral connective tissue and present as retropharyngeal and/or parapharyngeal masses [3].…”

“…SS typically show a t(x;18) translocation with fusion between SSX1 or SSX2 and SYT genes. FISH and RT-PCR have been employed for the rapid diagnosis of SS [1,3]. Since the first case of primary hypopharyngeal SS reported by Jernstorm [5], several independent case reports have been published.…”

“…Synovial sarcoma (SS) is a malignant neoplasm that arises from the primitive pluripotent mesenchymal cells near to or remote from the articular surfaces [1]. It is a relatively rare tumor, occurs mainly in adolescents and young adults, has a slight male predominance, and comprises approximately 10 % of all soft tissue sarcomas [2].…”