Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome complicated by seven pulmonary emboli in a 15-year old patient

Coloe, Jacquelyn; Diamantis, Stephanie; Henderson, Frederick W.; Morrell, Dean S.

doi:10.1016/j.jaad.2009.02.049

Cited by 14 publications

(16 citation statements)

References 9 publications

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“…TNF-α blockers have also been proven to be effective [16,[82][83][84][85]. There is no consensus, however, on the drug regimen that should be used.…”

Section: Treatmentmentioning

confidence: 99%

“…The classical course of CRMO is characterized by prolonged remissions with periods of exacerbations, with most cases Remission of the osteoarticular symptoms, new active bone lesions after 10 months of treatment detected by bone scan Wolber C et al [118] 1 SAPHO Etanercept Clinical improvement Coloe J et al [85] 1 SAPHO Etanercept Clinical improvement Wagner AD et al [119] 2 SAPHO Etanercept -1 patient Clinical and radiologic improvement Infliximab (5mg/kg on the first dose and 3 mg/kg thereafter every 4 weeks), due to bronchospam infliximab was discontinued and replaced by etanercept -1 patient Olivieri I et al [120] 2 SAPHO Infliximab (5 mg/kg) at weeks 0, 2, and 6 Clinical improvement Massara et al [121] 4 SAPHO Infliximab (5 mg/kg) at 0, 2 and 6 weeks followed by every 6 weeks thereafter…”

Section: Prognosismentioning

confidence: 99%

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Chronic Recurrent Multifocal Osteomyelitis

Costa-Reis

Sullivan

2013

J Clin Immunol

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Chronic recurrent multifocal osteomyelitis is a rare auto-inflammatory condition that primarily affects children and adolescents. It presents with recurrent episodes of pain related to the presence of foci of sterile bone inflammation. The long bones of the lower extremities are more frequently affected and the spine can also be involved. Imaging studies, including whole-body magnetic resonance, are important for diagnosis and detection of asymptomatic lesions. Bone biopsies may be necessary to exclude other diseases, including malignancy and infections. Non-steroidal anti-inflammatory drugs cause relief of symptoms in the majority of cases. Bisphosphonates and TNF-α blockers are alternatives for patients who do not respond or who have spinal involvement.

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“…TNF-α blockers have also been proven to be effective [16,[82][83][84][85]. There is no consensus, however, on the drug regimen that should be used.…”

Section: Treatmentmentioning

confidence: 99%

Section: Prognosismentioning

confidence: 99%

Chronic Recurrent Multifocal Osteomyelitis

Costa-Reis

Sullivan

2013

J Clin Immunol

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“…Cuatro de estos 14 pacientes presentaron, además, obstrucción a otros niveles: 2 en la vena cava superior, uno en la vena yugular y uno a nivel de la vena ilíaca derecha 5-7 . Coloe et al, describen un paciente que presentó obstrucción iliofemoral bilateral complicada con embolismo pulmonar 8 .…”

Section: Resultsunclassified

“…La duración de los síntomas tanto articulares como cutáneos fue superior 10 años. Ocho pacientes presentaron manifestaciones cutáneas, 6 en forma de pustulosis palmo-plantar y 2 con acné severo 5,6,8,9 . Dentro de las manifestaciones osteoarticulares, de los 9 pacientes que presentaron afectación de la pared torácica anterior (osteocondritis) 4,5,7-13 , 4 casos tenían asociada además artritis periférica (hombros) 4,5,7 y 2 afectación de la columna lumbar 5,11,13 .…”

Section: Resultsunclassified

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Manifestaciones trombóticas en el síndrome SAPHO. Revisión de la literatura

Carranco-Medina

Calleja

Calero-Paniagua

et al. 2015

Reumatología Clínica

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Cardiovascular disease in patients with autoinflammatory syndromes

et al. 2017

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Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. The link between AIS and cardiovascular disease is not that clear, even if the concept of continuous inflammation as a risk factor for cardiovascular disease is widely accepted. Research on the association of AIS and cardiovascular disease is increasing within the last years. In this review, we will discuss the association of several AIS with cardiovascular disease. Based on the rarity of some entities, lack of data, however, led to exclusion of some rare AIS. Especially, for Behcet's disease (BD), adult-onset Still's disease (AOSD), and Familial Mediterranean fever (FMF), there is an association with a number of cardiovascular abnormalities. BD is the AIS, which is most strongly associated with manifestation in the arterial and venous system. AOSD is strongly associated with cardiac inflammation (peri-/myocarditis). FMF patients are likely to suffer from serositis. Of note, there seems to be a link between variants of AOSD as well as FMF and idiopathic recurrent acute pericarditis.

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Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome complicated by seven pulmonary emboli in a 15-year old patient

Cited by 14 publications

References 9 publications

Chronic Recurrent Multifocal Osteomyelitis

Chronic Recurrent Multifocal Osteomyelitis

Manifestaciones trombóticas en el síndrome SAPHO. Revisión de la literatura

Cardiovascular disease in patients with autoinflammatory syndromes

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