Syntaxin 7 modulates seizure activity in epilepsy

Wu, Junhong; Zhang, Hui; Liu, Yang; Chen, Yuanyuan; Li, Jiyuan; Yang, Min; Zhang, Xiaogang; He, Chaojun; Wang, Xuefeng; Xu, Xin

doi:10.1016/j.nbd.2023.106118

Neurobiology of Disease

2023

DOI: 10.1016/j.nbd.2023.106118

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Syntaxin 7 modulates seizure activity in epilepsy

Junhong Wu¹,

Hui Zhang²,

Yang Liu³

et al.

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2024

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Cited by 3 publications

References 53 publications

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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations

Czapińska-Ciepiela,

Łuszczki,

Czapiński

et al. 2024

Pharmacol. Rep

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Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and brivaracetam show a high affinity to the synaptic vesicle protein type 2 A (SV2A), whereas pregabalin and gabapentin are selective ligands for the α2δ1 subunits of the voltage-gated calcium channels. In this paper, we present recent progress in understanding the significance of presynaptic release machinery in the neurochemical mechanisms of epilepsy and ASMs. Furthermore, we discuss whether the knowledge of the basic mechanisms of the presynaptically acting ASMs might help establish a rational polytherapy for drug-resistant epilepsy.

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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations

Czapińska-Ciepiela,

Łuszczki,

Czapiński

et al. 2024

Pharmacol. Rep

View full text Add to dashboard Cite

show abstract

SNARE proteins: Core engines of membrane fusion in cancer

Liu,

Dang,

Zhang

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy

Ban,

Yang,

Tan

et al. 2024

Neurochemistry International

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Syntaxin 7 modulates seizure activity in epilepsy

Cited by 3 publications

References 53 publications

Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations

Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations

SNARE proteins: Core engines of membrane fusion in cancer

Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy

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