Synthese des Vitamin A

Isler, O.; Huber, Walter; Ronco, Álvaro L.; Kofler, M.

doi:10.1002/hlca.19470300666

Cited by 230 publications

(67 citation statements)

References 14 publications

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“…Whilst this could be achieved with poisoned palladium on charcoal or palladium on calcium carbonate [35], selectivities were significantly higher with the lead-doped catalyst and the reaction could easily be stopped after the uptake of just one equivalent of hydrogen gas. From MBE, the chain is extended in a sequential manner to obtain dehydroisophytol (31, Scheme 9).…”

Section: Semi-hydrogenation Of C≡c Triple Bonds (Lindlar Type)mentioning

confidence: 99%

“…As an extension to the work above, another fragrance compound, dimethyloctenol (DMOE, 36), can be prepared by the combination of a hydrogenation of a C=C double bond and a selective semi-hydrogenation of a C≡C triple bond (Scheme 11). Methylheptenone (34) can be hydrogenated with a range of Pd/C or Pd/Al2O3 catalysts to give methylheptanone (35). The reaction was run without solvent at a range of temperatures (30-80 °C) and pressures (1-10 bar hydrogen).…”

Section: Semi-hydrogenation Of C≡c Triple Bonds (Lindlar Type)mentioning

confidence: 99%

See 1 more Smart Citation

Hydrogenation in the Vitamins and Fine Chemicals Industry – An Overview

Bonrath¹,

Medlock²,

Schütz³

et al. 2012

Hydrogenation

106

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Section: Semi-hydrogenation Of C≡c Triple Bonds (Lindlar Type)mentioning

confidence: 99%

Section: Semi-hydrogenation Of C≡c Triple Bonds (Lindlar Type)mentioning

confidence: 99%

Hydrogenation in the Vitamins and Fine Chemicals Industry – An Overview

Bonrath¹,

Medlock²,

Schütz³

et al. 2012

Hydrogenation

106

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“…The first synthesis of retinol was 149 performed by Isler et al (1947) and the first synthesis of β-carotene was reported by 150 Milas et al (1950). 151…”

mentioning

confidence: 99%

Microencapsulation of vitamin A: A review

Gonçalves

Estevinho

Rocha

2016

Trends in Food Science & Technology

133

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“…Later studies claimed that "Fat soluble A" (synonym to vitamin A) plays an important role in preventing night blindness and xeropthalmia (Goodman, 1984). Since 1930, developments in chemistry, cell biology and molecular biology have explored many pathways related to retinol and its precursors and scientists have successfully synthesized these compounds chemically (Isler et al, 1947). Another landmark in this area of study was the discovery of retinol binding proteins in animal tissues.…”

Section: Studies Carried Out By Mccollum and Davis In Early 19mentioning

confidence: 99%

Molecular mechanisms of reversing neural degeneration by retinoic acid, a major derivative of vitamin A

Ranaweera

Rajapakse

2017

Ceylon J. Sci.

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For the past hundred years since the discovery of vitamin A, the field of research associated with retinoids has been well evolved due to advances in molecular biology, chemistry, biochemistry and medicine. Vitamin A is an essential component in diet. Major derivatives of vitamin A such as retinol, retinaldehydes and retinoic acid are collectively considered as retinoids. Deficit of Vitamin A has a direct correlation with disease development in our body emphasizing the importance of retinol. Retinoic Acid is proclaimed as powerful mitogen acting in our body since the developmental embryonic stages where it is associated with many organ systems in body carrying out different functionalities. Retinoids carry out many functions of nervous systems. This review is mainly focused on contribution of Retinoic acid towards reversing the process of neural degeneration in pathological conditions achieved by neurodegenerative diseases and tumor inducing situations. Retinoids can act on neurons carrying morphogenesis of nerves by promoting stem cell differentiation. Activation of phospholipase A2 pathway can promote neural differentiation. Also by inactivating human Inhibitor of DNA binding 2 gene, retinols can suppress stem cell proliferation and initiate morphogenesis. This gene inactivation can be also used as a therapy to prevent malignant cell proliferation leading to tumors. Anti amyloidogenic activity is discussed in this review locates a significant importance in reversing neural degenerating process in diseased conditions. Moreover, Reactive Oxygen Species accumulation can be suppressed by Retinoic Acid where it can promote cell survival during pathological constrains. The revision of literature is carried out in depth revealing Retinoic Acid related putative drug target mechanisms, where we can use Retinoic Acid as a novel therapeutic drug in neurodegenerative diseases.

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Synthese des Vitamin A

Cited by 230 publications

References 14 publications

Hydrogenation in the Vitamins and Fine Chemicals Industry – An Overview

Hydrogenation in the Vitamins and Fine Chemicals Industry – An Overview

Microencapsulation of vitamin A: A review

Molecular mechanisms of reversing neural degeneration by retinoic acid, a major derivative of vitamin A

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