Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

Singh, Ravi S.; Singh, Dharmendra Kumar

doi:10.1155/2009/419214

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…1, 2, 4-Triazoles and their derivatives represent one of the most biologically active classes of compounds, possessing a wide range of therapeutic properties 4 . In views of these observations and in continuation of our earlier work [5][6][7][8][9][10][11] on the syntheses of some 1,2,4-and 1,2,3-triazole derivatives, we now report the syntheses of some more triazoles derived from 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole and their antifungal activity.…”

Section: Introductionsupporting

confidence: 57%

Syntheses of Some 3,5‐Diaryl‐4H‐1,2,4‐triazole Derivatives and their Antifungal Activity

Singh

2009

Journal of Chemistry

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Syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. In this present work, 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole(1) was converted toN,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine(2) and 3-Phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) in good yields by treatment with aldehydes OHC-C6H4-CHO and Ar-CHO respectively. The compoundsN,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine (2) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) were reduced with NaBH4to afford the corresponding compoundsN,N’-bis[3-phenyl-5--tolyl-4H-1,2,4-triazolyl]-1,4-xylenediamine (4) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylamino]-4H-1,2,4-triazole (5) respectively. The newly synthesized compounds were characterized by spectral and elemental analyses. All the synthesized compounds were tested for their antifungal activity againstP.oryzae, B. cinerea, A. niger, C. albicans and T. rubrum.

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Section: Introductionsupporting

confidence: 57%

Syntheses of Some 3,5‐Diaryl‐4H‐1,2,4‐triazole Derivatives and their Antifungal Activity

Singh

2009

Journal of Chemistry

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“…2,4-Dihydro-4-(4-methylphenyl)-5-(isomeric pyridyl)-3H-1,2,4-triazoles have been obtained by treating 1-(4-methylphenyl)-(isomeric pyridoyl) thiosemicarbazides and 2 M sodium hydroxide solution through the cyclization reaction. In views of these observations and in continuation of our earlier work [4][5][6][7][8] on the syntheses of some 1,2,4-&1,2,3-triazole derivatives, we now report the syntheses of some more triazoles derived from 1-(4-methylphenyl)-(isomeric pyridoyl) thiosemicarbazides and their antibacterial activities.…”

Section: Introductionsupporting

confidence: 53%

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents

Singh

2009

Journal of Chemistry

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A facile syntheses of 4-aryl-5-(isomeric pyridoyl)-3H-1, 2, 4-triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity againstS. aureus, E. coli, B. subtilisandP.aeruginosa.All compounds carrying 1, 2, 4- triazole moiety showed significant biological activity

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“…This include hepatitis C and hepatitis B and yellow fever. Taribavirin is as active against influenza as Ribavirin in animal models, with slight less toxicity, so it may also eventually replace Ribavirin as an anti-influenza agent 38 . Out of the ten compounds tested, compounds 3, 4and 10inhibited the formation of viral plaques by more than 30% at 50 mM after 48 hours postinfection and treatment.…”

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confidence: 99%

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2022

IJPSR

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Severe viral infections like Covid-19 are emerging now a day and are the common causes of human illness and death. Presently, we have a limited availability of antiviral chemotherapeutic agents to prevent and treat these infections, so it is the need of an hour to develop potential antiviral drugs against various harmful and fatal viral infections. A large quantity of research has been performed on 1,2,3 triazole and their derivatives, which has proved the promising antiviral activity of this heterocyclic nucleus. Among nitrogen-containing heterocyclic compounds, 1, 2, 3-triazoles are privileged structure motifs and received great attention in academics and industry. Even though absent in nature, 1, 2, 3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. 1, 2, 3 triazole nucleus is one of the most important and well-known heterocycle which is a common and integral skeleton of a variety of medicinal compounds like antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antiobesity and immunomodulatory agents, etc.1, 2, 3 triazole emerged as a pharmacologically significant scaffolds due to its broad and potent activity against severe infections. This review primarily lays emphasis on the recent advancements in the synthesis and biological evaluation of 1, 2, 3 triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents. INTRODUCTION:A virus is the smallest type of parasite to exist, usually ranging from 0.02 to 0.3μm in size, although some viruses can be as large as 1μm. They are about 1/100 th of the size of bacteria 1 .

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Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

Cited by 7 publications

References 5 publications

Syntheses of Some 3,5‐Diaryl‐4H‐1,2,4‐triazole Derivatives and their Antifungal Activity

Syntheses of Some 3,5‐Diaryl‐4H‐1,2,4‐triazole Derivatives and their Antifungal Activity

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents

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