Synthesis and Acaricidal Activity of Some New 1,2,4‐Triazine Derivatives

Abstract

A new series of 1,2,4‐triazine derivatives were designed, synthesized, and identified on the basis of IR, 1H‐NMR, 13C‐NMR, and EI‐MS spectral data. The potent acaricidal activity of 1,2,4‐triazine derivatives against eggs and adult female of Tetranychus urticae (Koch) was assessed compared with pyridaben under laboratory conditions. Structure acaricidal activity relationships of the promising 1,2,4‐triazine derivatives were analyzed for eggs and adult female; the nature and position of the substituents were important in demonstration of the activities.

Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

“…Aromatic as long as aliphatic carboxylic acids could be efficiently used and high yields were generally obtained. [148][149][150][151][152][153][154][155] Treatment with ethylcyanoacetate in polyphosphoric acid under heating produced acetate derivative 401 in good yield through elimination of ammonia. 156 Reaction with ethyl chloroformate delivered fused 1,3,4thiadiazolidin-2-one 402 while thione derivatives 403 were obtained by treatment with carbon disulfide in an ethanolic solution of potassium hydroxide.…”

“…57,157 Addition of ammonium thiocyanate to compound 399 in glacial acetic acid yielded fused 1,2,4-triazolidine-3-thione 404 157 while N-phenyl substituted derivative 405 has been produced in excellent yield by treatment with phenyl isothiocyanate in the presence of potassium carbonate. 148 (Scheme 82) <Scheme 82 near here>…”

An Efficient Approach for the Synthesis and Antitumor Evaluation of Novel Azo‐ and Anil‐Linked with 3‐Aminopyrazolo[3,4‐b]pyridine

“…In addition, iminopyrazole, pyrimidoquinoline derivatives, and pyridopyrazolpyrimidines are significant molecules that have gained a considerable amount of attention due to their wide variety of industrial and biomedical applications, including antitumor, [17,18] antibacterial, [19,20] antioxidant, [19] antifungal, [20,21] antimalarial, [22] anti‐inflammatory, [23,24] antiviral, [18] and an azo derivative that is effective in DNA cleaving [25] . Additionally, imines have been discovered to have cytotoxic and anti‐proliferative activity against some cancer cell lines, including (Panc‐1), (Caco‐2), and leukemia, [26,27] in which the azomethine link was thought to be vital for biological activity [28,29] …”

“…[25] Additionally, imines have been discovered to have cytotoxic and antiproliferative activity against some cancer cell lines, including (Panc-1), (Caco-2), and leukemia, [26,27] in which the azomethine link was thought to be vital for biological activity. [28,29] Herein, we introduce an efficient method for synthesizing an azo-and anil-linked with 3-aminopyrazolo [3,4-b]pyridine derivatives and tested their cytotoxic activity against the A2780CP, MCF-7, and HepG-2 cell lines.…”