2016
DOI: 10.1016/j.bmcl.2016.04.096
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Synthesis and anti-proliferative activity of fluoro-substituted chalcones

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Cited by 52 publications
(34 citation statements)
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“…Fluorine affects the bonding interactions and metabolic stabilities of compounds and has an impact on their physical features and selective reactivity [ 44 ]. Burmaoglu and colleagues [ 45 ] synthesized a series of bioisosteric molecules with anticancer activity, starting from a 2′,4′,6′-trimethoxy-chalcone ( 7 ) structure. Potent anticancer effects were reported for some of these bioisosteres.…”
Section: Design Of New Chalcone Derivativesmentioning
confidence: 99%
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“…Fluorine affects the bonding interactions and metabolic stabilities of compounds and has an impact on their physical features and selective reactivity [ 44 ]. Burmaoglu and colleagues [ 45 ] synthesized a series of bioisosteric molecules with anticancer activity, starting from a 2′,4′,6′-trimethoxy-chalcone ( 7 ) structure. Potent anticancer effects were reported for some of these bioisosteres.…”
Section: Design Of New Chalcone Derivativesmentioning
confidence: 99%
“…Potent anticancer effects were reported for some of these bioisosteres. Of particular interest was derivative 8 ( Figure 3 ), displaying potencies (IC 50 ) ranging from 0.030 to 0.120 μM on a panel of cervical cancer (HeLa), lung adenocarcinoma epithelial (A549), renal cancer (A498), skin malignant melanoma (A375), and hepatocellular carcinoma (HepG2) cell lineages [ 45 ].…”
Section: Design Of New Chalcone Derivativesmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, the new drug researches for cancer chemotherapy continue. An important part of the studies on this topic has focused on natural products (Burmaoglu et al, 2016). Because its many pharmacological features, Hypericum perforatum L. is interesting plant species for cancer research.…”
Section: Introductionmentioning
confidence: 99%
“…5 Chalcones, with an aromatic enone as a central core, showed anti-inammatory, 6 anti-histaminic, 7 anti-oxidant, 8 anti-protozoal, 9 antibacterial, 10 antimalarial, 11 antifungal, 12 anti-HIV 13 activities. Moreover, chalcones have shown potent inhibition of several anticancer targets, including thioredoxin reductase, and tubulin polymerization 14,15 and by preferentially killing cancer cells over non-cancer cells. 16 In this context, to improve the efficacy of chalcones while evading drug-resistance, molecular hybridization involving dual-or multi-target approach has been investigated.…”
Section: Introductionmentioning
confidence: 99%