Synthesis and Anticancer Evaluation of Some New Hydrazone Derivatives of 2,6‐Dimethylimidazo[2,1‐b][1,3,4]thiadiazole‐5‐carbohydrazide.

Terzioglu, Nalan; Guersoy, A.

doi:10.1002/chin.200401111

Cited by 15 publications

(19 citation statements)

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“…In addition, coumarins can inhibit the proliferation of cancer cells by stopping the progression of cells in G0/G1, G2//M phases (Chen et al, 2012) and hydrazide-hydrazone (CO -NH -N = CH) motherhood play an important role as an antitumor agent (Kumar et al, 2012;Terzioglu and A, 2003).…”

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Al-awad

raheem

Jaccob

2020

ijrps

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The current work focuses on new architecture, synthesis of coumarin-oxadiazole hybrid derivative products as both these (coumarin ring and oxadiazole) have a wide variety of biological behavior, Compounds containing the nucleus of coumarin (2H-1-benzopyran-2-one) are an interesting class of hetero cycles which hold an important role in the field of natural ingredients and synthetic organic chemistry. It has been exciting medicinal chemists to study native coumarins or synthetic analogs for their application for decades. And they can be further modified to synthesize more effective and potent drugs. Compounds have been characterized by spectrophotometry of physicochemical properties and their structures verified by infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H-NMR) Such new derivatives of coumarinyl-oxadiazole was qualified to estimate the lethal dose, anticancer, anticoagulant and antioxidant activity. Their pharmacological properties depend on their pattern of substitution, compound S4F proved significant anticoagulant activity in concentration (50, 100, 200 mg/ml) similar for heparin, and monitor the coagulation effect on plasma, while compound S4CO give significant anticancer activity against MCF-7 a breast cancer cell. Specific compounds have strong antioxidants with the effective action of radical scavengers; the S4Cl compound with IC50 1.49 is the most potent antioxidant activity note. Basically, all the formulations tested reported satisfactory behavior. The review shows that varieties of coumarin derivatives have synthesized and shown anti-cancer, antioxidant and anti-coagulant potentials. These derivatives synthesis and its biological assay can be further modified in the future to improve the anti-cancer, anti-oxidant and anticoagulant potentials of the versatile coumarin nucleus.

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Section: Anticancer Activitymentioning

confidence: 99%

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Al-awad

raheem

Jaccob

2020

ijrps

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“…The acylhydrazones [(hydrazide-hydrazone (ACOANHA N‚CHA)] are classified as important functional group which exhibit significant role in anti-inflammatory (Todeschini et al, 1998;Radhwan et al, 2007;Gaston et al, 1996;Almasirad et al, 2005;Murineddu et al, 2001), antimalarial (Gemma et al, 2006), antimicrobial (Masunari and Tavares, 2007;Kuc¸ukguzel et al, 2002), anticonvulsant (Dimmock et al, 2000;Ragavendran et al, 2007), antitumor (Bernhardt et al, 2009;Whitnall et al, 2006;Vicini et al, 2006;Terzioglu and Gursoy, 2003;Abadi et al, 2003), analgesic (Lima et al, 2000), antiplatelet (Silva et al, 2004) and antitubercular (Vavrikova et al, 2011a;Manvar et al, 2008;Vavrikova et al, 2011b) activities. In recent years, researchers have turned their interest by replacing the central heterocyclic spacer of the bis(indole) alkaloids with biologically active long chain linkers such as glyoxylamide derivatives , and acylhydrazones and their cytotoxic activity was evaluated against human cancer cell lines (Kumar et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Synthesis, characterization and cytotoxic investigations of novel bis(indole) analogues besides antimicrobial study

Choppara

Bethu

Prasad

et al. 2019

Arabian Journal of Chemistry

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Two series of novel bis(indole) analogues viz., N 0 -((5-substituted-1H-indol-3-yl)methylene)-n-(1H-indol-3-yl)alkanehydrazides (7a-f) and N 0 -((5-substituted-1-(3-methylbut-2-e nyl)-1H-indol-3-yl)methylene)-n-(1H-indol-3-yl)acetohydrazide (8a-f) were synthesized and characterized by spectral analysis. The target molecules were screened for their antimicrobial, anticancer activities and structure and activity relationship (SAR) was investigated. Compounds 7a, 7c and 8a were found to be active in antimicrobial screening. Anticancer screening reveals that Compound 7c was active against HeLa cell line with an IC 50 of 43.1 lM and compound 7d was found to be interesting candidate with an IC 50 of 26.0 and 30.2 lM against Colo-205 and Hep G2 cell lines respectively. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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“…The chemistry of hydrazones and their metal complexes has long been an area of active interest because of their properties appropriate for their applications in, for example, sensors, non‐linear optical and polymeric materials and their biological applications. Hydrazide–hydrazone derivatives have been reported to possess interesting bioactivity such as antibacterial, anticonvulsant, anti‐inflammatory, antimalarial, analgesic, antiplatelets, antituberculosis and anticancer activities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1, 5‐a]pyridine derivatives bearing a hydrazone moiety

Zhang

et al. 2013

Luminescence

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A series of novel imidazo[1,5-a]pyridine-hydrazone derivatives were synthesized and characterized by infrared spectroscopy (IR), 1H NMR, 13C NMR and high resolution mass spectrometer (HRMS). Typically, the spatial structure of compound 3j was determined using X-ray diffraction analysis. The UV-vis absorption and fluorescence spectral characteristics of the compounds in dichloromethane and acetonitrile were investigated. Absorption peaks could be observed in the wavelength range 290-450 nm. It can also be seen that they display very similar maximum emission. The group attached to hydrazone hardly influenced the maximum emission. Furthermore, all the compounds were evaluated for antibacterial activity and were found to be more effective against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella compared with chloramphenicol.

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Synthesis and Anticancer Evaluation of Some New Hydrazone Derivatives of 2,6‐Dimethylimidazo[2,1‐b][1,3,4]thiadiazole‐5‐carbohydrazide.

Cited by 15 publications

References 1 publication

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Synthesis, characterization and cytotoxic investigations of novel bis(indole) analogues besides antimicrobial study

Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1, 5‐a]pyridine derivatives bearing a hydrazone moiety

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