Synthesis and antimicrobial evaluation of some novel dithiolane, thiophene, coumarin, and 2-pyridone derivatives

Mahmoud, Mahmoud R.; El‐Azm, Fatma S. M. Abu; Ali, Amira T.; Ali, Yasmeen M.

doi:10.1080/00397911.2017.1336776

Cited by 17 publications

(5 citation statements)

References 32 publications

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“…Besides the abovementioned coumarin hybrids, coumarin–pyridine hybrids, [ 116–118 ] coumarin–imine hybrids, [ 119–122 ] coumarin–peptide hybrids, [ 123 ] coumarin–indole hybrids, [ 124 ] coumarin–sulfonamide hybrids, [ 125 ] coumarin–ferrocene hybrids, [ 126 ] coumarin–thiazine hybrids, [ 127 ] coumarin–sugar hybrids, [ 128 ] coumarin–pyran hybrids, [ 129 ] and coumarin–glyoxal hybrids [ 130 ] also showed certain antibacterial activity, but the majority of them were far less potent than the reference drugs. Hence, the enriched SAR may pave the way for further rational design of the novel coumarin hybrids.…”

Section: Miscellaneous Coumarin Hybridsmentioning

confidence: 99%

Coumarin‐containing hybrids and their antibacterial activities

Feng

Zhang

Yang

et al. 2020

Archiv der Pharmazie

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Infections caused by Gram-positive and -negative bacteria are one of the foremost causes of morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial infections, but the emergence and wide spread of drug-resistant pathogens have already become a huge issue for public healthcare systems. The coumarin moiety, which is ubiquitous in nature, could bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by blocking the ATPase activity; hence, coumarin derivatives possess potential antibacterial activity. Several coumarin-containing hybrids such as coumermycin A1, clorobiocin, and novobiocin have already been used in clinical practice for the treatment of various bacterial infections; thus, it is conceivable that hybridization of the coumarin moiety with other antibacterial pharmacophores may provide opportunities for the development of novel antibiotics. This review outlines the advances in coumarin-containing hybrids with antibacterial potential in the recent 5 years and the structure-activity relationships are also discussed. K E Y W O R D S antibacterial, coumarin, hybrid compounds, structure-activity relationships

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Section: Miscellaneous Coumarin Hybridsmentioning

confidence: 99%

Coumarin‐containing hybrids and their antibacterial activities

Feng

Zhang

Yang

et al. 2020

Archiv der Pharmazie

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“…[22][23][24][25][26] So that, cyanoacetohydrazide is a privileged starting molecule for developing possible bioactive agents, and their derivatives represent an important class of heterocyclic compounds, they exhibited a wide spectrum of bioactivity. For example, antitumor, [27][28][29] anti-fungal, 30 anti-inammatory, 31,32 anti-microbial, 33,34 as well as insecticidal 35,36 and corrosion inhibitory activities. 37 Noteworthy, it is well known that the ultrasonic energy has become widely used in pharmaceutical and industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic-induced synthesis of novel diverse arylidenes via Knoevenagel condensation reaction. Antitumor, QSAR, docking and DFT assessment

El-Sayed Ebead,

Aboelnaga,

Nassar

et al. 2023

RSC Adv.

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“…SAR revealed that improved antimicrobial activity is due to the larger size of sulfur atom (Fig. ) .…”

Section: Introductionmentioning

confidence: 99%

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Mishra

Sachan

Kumar

et al. 2018

Journal of Heterocyclic Chem

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Thiophene has emerged as a potent scaffold that has pulled the keen interest of the researchers because of its considerable diversity in biological activities. The versatility of the thiophene nucleus is demonstrated by the successful introduction of its derivatives, which have anti‐inflammatory (Thenaldine), anticancer (Ralitrexed), antioxidant (Erdosteine), and antimicrobial (Cefoxitin and Temocillin) activities. This decent variety in the biological response profile has pulled in the consideration of numerous researchers to research this skeleton to its distinctive potential against several activities. This review is integral to prior reviews and plans to review the work regarding antibacterial and antifungal activities of thiophene, substituted thiophene and thiophene‐like compounds, and also Schiff bases of thiophene and substituted thiophenes from year 1995 to the beginning of 2018.

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Synthesis and antimicrobial evaluation of some novel dithiolane, thiophene, coumarin, and 2-pyridone derivatives

Cited by 17 publications

References 32 publications

Coumarin‐containing hybrids and their antibacterial activities

Coumarin‐containing hybrids and their antibacterial activities

Ultrasonic-induced synthesis of novel diverse arylidenes via Knoevenagel condensation reaction. Antitumor, QSAR, docking and DFT assessment

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

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