Synthesis and Antimicrobial Screening of 2‐Aryl‐5‐((2‐arylthiazol‐4‐yl)methyl)‐1,3,4‐oxadiazole Derivatives

Abstract

A new series of 2‐aryl‐5‐((2‐arylthiazol‐4‐yl)methyl)‐1,3,4‐oxadiazole derivatives was synthesized by condensation of 2‐(2‐substituted thiazol‐4‐yl)acetohydrazide with aryl aldehydes followed by oxidative cyclocondensation using iodobenzene diacetate. The structure of synthesized compounds was characterized by IR, NMR, and mass analysis. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity. Some of the compounds showed moderate antimicrobial activity.

Synthesis and biological evaluation of new 4‐(4‐(1‐benzyl‐1H‐1,2,3‐triazol‐4‐yl)phenyl)‐2‐phenylthiazole derivatives

“…The structure of intermediate was confirmed by 1 H NMR and LCMS analysis and the structure final compounds 8a-l were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS analysis. As a representative analysis of compound 4-(4-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl)-2-phenylthiazole, 8a, the 1 H NMR spectrum of compound 8a showed one singlet in aliphatic region at δ 5.52 (Ar-CH 2 -triazole), and two singlets at δ 7.22 and 8.41 correspond to C-4 proton of 1,2,3-triazole and C-5 proton of thiazole, respectively.…”

“…The synthesis of clubbed 1,2,3‐triazole and thiazole core has received significance in recent years because of their significant antibacterial and antitubercular activities. Thiazole‐containing compounds are therapeutically important in medicinal chemistry; they showed antimicrobial, antifungal, antitubercular, anticancer, anti‐inflammatory, and antiviral activities. 1,2,3‐Triazole derivatives are important class of bioactive molecules.…”

“…1H);13 C NMR (126 MHz, DMSO) δ 53.55 (CH 2 , N-CH 2 -Ar), 115.77, 122.29, 126.05, 127.14, 128.40, 128.43, 128.68, 129.31, 129.84, 130.95, 132.27, 133.70, 135.42, 136.47, 146.79, 155.37, 166.15; HRMS m/z = 429.0932 (M + H) + .…”