Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1h- indol- 2, 3- diones

Yurttaş, Leyla; Ertaş, Merve; Cankılıç, Meral Yılmaz; Demirayak, Şeref

doi:10.23893/1307-2080.aps.0554

Cited by 8 publications

(6 citation statements)

References 24 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yurttaşet al synthesized a series of isatin-thiazole-based hydrazones and screened their antimycobacterial activity against the H 37 Rv strain. The synthesized compounds 68a and 68b , having 4-hydroxyphenyl and 2-pyridyl moiety, respectively, exhibited significant activity (MIC = 15.63 μg/mL) two-fold greater than isoniazid (MIC = 31.25 μg/mL) ( Figure 11 ) [ 85 ].…”

Section: Antimycobacterial/tubercular Activities Of Isatin-based Scaf...mentioning

confidence: 99%

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

et al. 2022

View full text Add to dashboard Cite

Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in trials. Apart from its promising antiproliferative properties, isatin has shown potential in treating Neglected Tropical Diseases (NTDs) not only as a parent core, but also by attenuating the activities of various pharmacophores. The objective of this mini-review is to keep readers up to date on the latest developments in the biological potential of isatin-based scaffolds, targeting cancer and NTDs such as tuberculosis, malaria, and microbial infections.

show abstract

Section: Antimycobacterial/tubercular Activities Of Isatin-based Scaf...mentioning

confidence: 99%

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Oxindole derivatives with substitutions at the N-1, C-3, C-4, and C-5 positions have exhibited antibacterial activity. For a comprehensive review of these compounds, please refer to references [58][59][60].…”

Section: Oxindole Alkaloidsmentioning

confidence: 99%

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Blanck¹,

Huebner²,

Rolls³

et al. 2022

AppliedChem

View full text Add to dashboard Cite

Cat’s claw (Uncaria tomentosa (Willd. ex Schults) DC.), a plant that is exceptionally rich in phytochemicals, has been used for centuries by the indigenous people of South and Central America as a therapeutic and is currently widely exported for medicinal purposes. Extracts and individual components have shown considerable potential as antibacterials in the literature. The purpose of this review is twofold: first, to provide a substantiated, comprehensive collection of the known chemical constituents of U. tomentosa, including their detailed structures; second, to identify those components that offer some promise as antibacterials based on the research to date. Bacterial resistance to currently available antibiotics continues to increase and is widely recognized as an impending, potentially catastrophic, problem. There is research to suggest that U. tomentosa components may have antibacterial potential individually or synergistically with established antibiotics against microbes, including Borrelia burgdorferi, the causative agent of Lyme disease. It is our intention that this review will provide a valuable resource to investigators in search of new antimicrobials to meet the daunting challenge of antibiotic resistance.

show abstract

“…İndazol türevleri anti-inflamatuar, antibakteriyel, anti-HIV, antiaritmikler, antifungal ve antitümör gibi geniş biyolojik aktivite yelpazesine sahiptir [23]. Antimikobakteriyel olarak aktif olan birçok farmakolojik ürünün yapısında mevcuttur [24][25][26][27]. 7-Nitro İndazol ile benzeri bir yapıya sahip olan 1H,1'H-3,3'-biindazol de indol ve indazol halkaları arasında π konjikasyonlu yapıya sahiptir.…”

Section: Bulgular Ve Tartişmaunclassified

“…temizleyicisi olduğu bildirilmiştir [11]. Özellikle indazol ve indazol analogları kanser tedavisinde hayati önem taşırlar [12,13].…”

Section: Introductionunclassified

1H, 1'H-3,3'-Biindazol Maddesinin Ratlarda Bazı Biyokimyasal Parametrelere Etkisinin Araştırılması

Çöteli

Karataş

Kara

et al. 2022

Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi

View full text Add to dashboard Cite

İndazoller kimya ve farmakoloji’de önemli bileşiklerdir. Bu çalışmada, ratlara belirli sürelerde enjekte edilen 1H,1'H-3,3'-biindazol maddesinin, ratların kan serumu, karaciğer ve böbrekteki antioksidan vitaminler (A, E, C), Se, MDA miktarları ile GSH-Px enzim aktiviteleri üzerine etkilerinin araştırılması amaçlanmıştır. Serum, karaciğer ve böbrek numunelerindeki selenyum miktarları florimetrik metotla, A, E, C ve MDA seviyeleri ise yüksek performanslı sıvı kromatografisi (HPLC) ile belirlenmiştir. Eritrositlerin GSH-Px enzim aktivite miktarları spektrofotometrik metotla ölçülmüştür. Deneysel sonuçlarımız, A, E, C vitaminleri ve Se düzeylerinin genel olarak kontrol grubuna göre daha düşük olduğu, 3. enjeksiyon periyodunda GSH-Px enzim aktivite miktarının maksimum arttığı ve diğer enjeksiyon periyodlarındaki aktivitelerin kontrol grubuna göre daha yüksek olduğu gözlenmiştir. 1H,1'H-3,3'-biindazolmaddesi uygulamasından sonra ratların A, E, C vitaminleri ve Se düzeyleri azalırken, MDA seviyeleri ve GSH-Px enzim aktivite miktarlarının arttığı tespit edilmiştir. Pek çok hastalığın tedavisinde kullanılan bu tıbbi maddelerin hayati önem taşıdığı ancak metabolizmada oksidatif strese yol açtığı belirlenmiştir. Bu maddeleri içeren ilaçların kullanımlarında antioksidan vitaminlerin ve selenium desteğinin faydalı olabileceği kanaatine varılmıştır.

show abstract

Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1h- indol- 2, 3- diones

Cited by 8 publications

References 24 publications

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

1H, 1'H-3,3'-Biindazol Maddesinin Ratlarda Bazı Biyokimyasal Parametrelere Etkisinin Araştırılması

Contact Info

Product

Resources

About