Synthesis and Antitumor Activity Evaluation of 3,6-Substituted- 1,2,4-triazolo[3,4-a]phthalazine Derivatives

Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives

“…[12] In this work, we replaced methylidene pyridine group with phenyl group to increase the lipophilic and stereo regular effect of the compounds. In order to increase the length and hydrophilicity of the compounds, a series of 1-phenyl-4-thiopthalazine and 1-phenyl-4-piperazinylphthalazine compounds were synthesized (Figure 1).…”