Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines

Synthesis and in vitro evaluation of novel tetralin‐pyrazolo[3,4‐b]pyridine hybrids as potential anticancer agents

“…The anticancer activities on HCT116 (colorectal carcinoma) and MCF‐7 (human breast adenocarcinoma) human cell lines were assessed using the 3‐[4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2 H ‐tetrazolium bromide (MTT) assay . These cancer cell lines were purchased from ATCC (Rockville, MD, USA).…”

Synthesis of furo[3,2‐g]chromones under microwave irradiation and their antitumor activity evaluation

“…[42][43][44] Cells were dispensed in a 96-well sterile microplate (5 × 10 4 cells/well) and incubated at 37°C with series of different concentrations, in DMSO, of each tested compound or Doxorubicin (positive control) for 48 hours in a serum free medium prior to the MTT assay. [42][43][44] Cells were dispensed in a 96-well sterile microplate (5 × 10 4 cells/well) and incubated at 37°C with series of different concentrations, in DMSO, of each tested compound or Doxorubicin (positive control) for 48 hours in a serum free medium prior to the MTT assay.…”

V2O5/SiO2 as an efficient catalyst in the synthesis of 5-amino- pyrazole derivatives under solvent free condition

“…In addition, compound C showed antitumor activity by inhibition of cyclindependent kinases (CDK) [3] (Figure 1). Furthermore, pyrazole compounds used as intermediates in the synthesis of various bioactive compounds such as pyrazolopyrimidines, pyrazolotriazines, pyrazoloquinazolines and Schiff bases [4][5][6][7][8][9]. A recent review of 5-aminopyrazoles described the miscellaneous synthetic methods [10] as the condensation of β-ketonitriles [11] or malononitrile derivatives [12] with hydrazine hydrate.…”