Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives

Cheng, Jun; Xie, Jiangtao; Luo, Xiaobing

doi:10.1016/j.bmcl.2004.10.087

Cited by 106 publications

(30 citation statements)

References 7 publications

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“…33,34 Our results also prove that novel modifications of amidinobenzimidazole molecules with the 2-pyridyl substituent at position C-2 could enrich their antiviral potentials and direct the synthetic research to novel antiviral lead molecules.…”

Section: Resultssupporting

confidence: 54%

Synthesis, Antiviral and Antitumor Activity of 2‐Substituted‐5‐amidino‐benzimidazoles.

et al. 2007

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We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Interestingly, all compounds show remarkable selectivity towards breast cancer cell line MCF-7. The most distinct and selective antiviral activity towards Coxackieviruses and Echoviruses was observed with compounds having pyridine ring at C-2. Especially interesting was fairly strong activity of 4 and 8 toward adenoviruses, which could be considered as leads against adenoviral replication.

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Section: Resultssupporting

confidence: 54%

Synthesis, Antiviral and Antitumor Activity of 2‐Substituted‐5‐amidino‐benzimidazoles.

et al. 2007

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“…Compounds derived from the 3-substituted pyridine are good lyase inhibitors (Hart et al, 2004), metabotropic glutamate subtype 5 (mGluR5) antagonists (Iso et al, 2006) and anti-inflammatory agents (Rabea et al, 2006) while 4-pyridyl derivatives have pronounced antiviral (Cheng et al, 2005), aromatase inhibiting (Bayer et al, 1991), p38 MAP kinase inhibiting (Miwatashi et al, 2005) and anticonvulsant activities (Mohammad and Mohammad, 2009). Sulfanilamide derivatives of the 2-amino-4-ethoxycarbonyl-pyridine have pronounced antibacterial activity (Abd El-Salam et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies

Arif

Jabeen

Saeed

et al. 2017

Bangladesh J Pharmacol

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Two new pharmacologically active series of tetrazolopyridine-acetohydrazide conjugates [9 (a-n), 10 (a-n)] were synthesized by reacting a variety of suitably substituted benzaldehydes and isomeric 2-(5-(pyridin-3/4-yl)-2H-tetrazol-2-yl)acetohydrazides (7, 8). The synthesized compounds were analyzed through FTIR, 1H NMR, 13C NMR and elemental techniques. These acetohydrazides were screened for their in vivo antidiabetic activity and molecular docking studies. An excellent agreement was obtained as the best docked poses show-ed important binding features mostly based on interactions due to an oxygen atom and aromatic moieties of the series. The compounds 9a, 9c and 10l were found to be the most active in lowering blood glucose, having the potential of being good antidiabetic agents.Video Clip of Methodology:Synthesis of 3/4-(2H-tetrazole-5-yl)pyridine: 1 min 57 sec <a href="https://www.youtube.com/v/CHp8HxlEa2M">Full Screen</a> <a href="https://www.youtube.com/watch?v=CHp8HxlEa2M">Alternate</a>

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“…Imidazoles are one of the interesting heterocycles which employed widely in medicine chemistry and their unique biological activities such as antiinflammatory [5], anti-parasitic [6], antifungal [7], antiviral [8].…”

Section: Introductionmentioning

confidence: 99%

Magnetic halloysite: an envirmental nanocatalyst for the synthesis of benzoimidazoles

Maleki

Hajizadeh

2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

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In the present work, halloysite nanotubes was modified by magnetic nanoparticles and used as an efficient, eco-friendly catalyst in synthesize of benzoimidazole derivatives. This synthesized nanocomposite was characterized successfully by Fourier transforms infrared spectroscopy (FT-IR), scanning electron microscopy (SEM). The catalyst can simply be separated from the reaction mixture by an external magnet and reused in several runs. Reusable and easily recoverable catalyst, use of green solvent, room temperature and mild reaction conditions are some advantages of the present work.

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Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives

Cited by 106 publications

References 7 publications

Synthesis, Antiviral and Antitumor Activity of 2‐Substituted‐5‐amidino‐benzimidazoles.

Synthesis, Antiviral and Antitumor Activity of 2‐Substituted‐5‐amidino‐benzimidazoles.

A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies

<strong>Magnetic halloysite: an envirmental nanocatalyst for the synthesis of benzoimidazoles</strong>

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