Synthesis and antiviral activity evaluation of some new cyclohexylidenehydrazide derivatives of 1,3-thiazole core

Abstract

Six novel cyclohexylidenehydrazide derivatives carrying five membered heterocyclic ring, 1,3-thiazole were synthesized to investigate their antiviral (including anti-HIV) activity against diverse DNA and RNA viruses in CRFK, HeLa, HEL, MDCK, Vero and MT4 cell cultures. None of the compounds was found active against any of the DNA or RNA viruses at 100 μM.

Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

“…The 1,3-thiazole motif is one of the backbones of many bioactive natural products, such as vitamin B1 (thiamine), micrococcin, and thiostrepton . Thiazole-containing compounds are known for their broad medicinal and biological activities, including antitumor, anticancer, antiviral, anti-inflammatory, antitubercular, antibacterial, antifungal, antimalarial, antihypertensive, and anti-HIV (Figure A)…”

“…The 1,3-thiazole motif is one of the backbones of many bioactive natural products, such as vitamin B1 (thiamine), 1 micrococcin, 2 and thiostrepton. 3 Thiazolecontaining compounds are known for their broad medicinal and biological activities, including antitumor, 4 anticancer, 5 antiviral, 6 anti-inflammatory, 7 antitubercular, 8 antibacterial, 9 antifungal, 10 antimalarial, 11 antihypertensive, 12 and anti-HIV (Figure 1A). 13 Furthermore, 2-aminothiazole as a derivative of this azoles, exhibits various medicinal and biological activities which have been utilized widely in the treatment of depression (Figure 1B), 14 inflammation (Figure 1C), 15 schizophrenia, 16 tuberculosis, 17 Parkinson's disease, 18 ulcers, 19 and HIV infections.…”