Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer

Tong, Liangqian; Zhao, Ming; Shu, Zhu; Chen, Jing

doi:10.1007/s11684-011-0162-6

Cited by 47 publications

(32 citation statements)

References 55 publications

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“…[1][2][3][4] However, the difficulty of evaluating and determining the precise contribution of each mechanism involved in cell-based treatments is one of the obstacles to their approval for clinical use. 5,6 Methods to determine the biodistribution and fate of injected cells are required to understand and refine stem cell therapies in patients.…”

Section: Introductionmentioning

confidence: 99%

“…120 In another study, the authors were able to follow SPION-labeled bone marrow progenitor cells by MRI in heart tissue for weeks after intracoronary injection, but a very large number (13×10 6 ) of cells were used in this study. 121 Also using a very large number (100×10 6 ) of SPION-labeled mesenchymal stem cells delivered by intrapericardial administration in porcine models, the authors identified a significant number of cells retained in the cardiac tissue a few days after injection. 122 In small rodents, it was possible to observe SPION-labeled mesenchymal stem cells (Endorem) after direct injection into the myocardial infarction scar.…”

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confidence: 99%

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Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Jasmin¹,

Souza²,

Louzada³

et al. 2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Jasmin¹,

Souza²,

Louzada³

et al. 2017

IJN

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“…The nanoscale structure and features of superparamagnetism offer a variety of possibilities for treatment and diagnostic medical applications. 1 SPIONs are used as tracer material in magnetic particle imaging (MPI). MPI was introduced in 2005 as a novel tomographic imaging modality.…”

Section: Introductionmentioning

confidence: 99%

Biological impact of superparamagnetic iron oxide nanoparticles for magnetic particle imaging of head and neck cancer cells

Lindemann¹,

Lüdtke‐Buzug²,

Fräderich³

et al. 2014

IJN

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Background As a tomographic imaging technology, magnetic particle imaging (MPI) allows high spatial resolution and sensitivity, and the possibility to create real-time images by determining the spatial distribution of magnetic particles. To ensure a prospective biosafe application of UL-D (University of Luebeck-Dextran coated superparamagnetic nanoparticles), we evaluated the biocompatibility of superparamagnetic iron oxide nanoparticles (SPIONs), their impact on biological properties, and their cellular uptake using head and neck squamous cancer cells (HNSCCs). Methods SPIONs that met specific MPI requirements were synthesized as tracers. Labeling and uptake efficiency were analyzed by hematoxylin and eosin staining and magnetic particle spectrometry. Flow cytometry, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays, and real-time cell analyzer assays were used to investigate apoptosis, proliferation, and the cytokine response of SPION-labeled cells. The production of reactive oxygen species (ROS) was determined using a fluorescent dye. Experimental results were compared to the contrast agent Resovist ® , a standard agent used in MPI. Results UL-D nanoparticles and Resovist particles were taken up in vitro by HNSCCs via unspecific phagocytosis followed by cytosolic accumulation. To evaluate toxicity, flow cytometry analysis was performed; results showed that dose- and time-dependent administration of Resovist induced apoptosis whereas cell viability of UL-D-labeled cells was not altered. We observed decreased cell proliferation in response to increased SPION concentrations. An intracellular production of ROS could not be detected, suggesting that the particles did not cause oxidative stress. Tumor necrosis factor alpha (TNF-α) and interleukins IL-6, IL-8, and IL-1β were measured to distinguish inflammatory responses. Only the primary tumor cell line labeled with >0.5 mM Resovist showed a significant increase in IL-1β secretion. Conclusion Our data suggest that UL-D SPIONs are a promising tracer material for use in innovative tumor cell analysis in MPI.

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“…NPs possess unique properties that enable them to be used as imaging probes, which may be traced via magnetic resonance imaging (MRI) and therapeutic agents at the same time (14); however, they can be further loaded to deliver specific drugs (15)(16) or target specific molecules (17,18). Superparamagnetic iron oxide (SPIO), known to be a highly efficient T 2 contrast agent for MRI, is an ideal small molecular probe for medical use (19). Although SPIO exploit an enhanced permeability and retention effect (EPR) for tumor uptake, EPR is still inefficient with relatively low concentrations of NPs reaching tumors (20).…”

Section: Introductionmentioning

confidence: 99%

Target‑specific delivery of oxaliplatin to HER2‑positive gastric cancer cells inï¿½vivo using oxaliplatin‑au‑fe3o4‑herceptin nanoparticles

Liu

Chen

et al. 2018

Oncol Lett

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Abstract. Gastric cancer is the fourth most common malignancy globally. In order to decrease the dosage and side effects of conventional chemotherapy, and achieve improved benefits from molecular targeted therapy, novel drug delivery systems were developed in the present study. Oxaliplatin-Au-Fe 3 O 4 -Herceptin ® acts as a dual-functional nanoparticles (NPs) conjugate and possesses the capability of human epithelial growth factor receptor 2 (HER2) targeting and oxaliplatin delivery. The 8-20 nm Au-Fe 3 O 4 were synthesized by decomposing iron pentacarbonyl on the surfaces of Au NPs in the presence of oleic acid and oleylamine. Following being coated with polyethylene glycol, the NPs possessed a ζ-potential of 13.8±1.6 mV and were demonstrated to exhibit no cytotoxicity when Fe concentration is <100 µg/ml via an MTS assay. Mass spectrometry analysis detected a peak at m/z 148,000, and Nuclear Magnetic Resonance indicated peaks at δ 3.51 (8.00H, s, 3-H), 2.97-3.02 (3.80H, t, 2-H) and 2.72-2.76 (3.72H, t, 1-H) following successful loading with Herceptin and oxaliplatin probes. A drug release assay via dialysis cassettes demonstrated that 25% of the oxaliplatin was released at pH 8.0, however >58% was released at pH 6.0 following 4 h incubation, indicating its pH-dependent release characteristic. The active targeting feature of oxaliplatin-Au-Fe 3 O 4 -Herceptin was verified in a subcutaneous xenograft mouse model containing SGC-7901 cells via detecting aggregated low intensity in T 2 -weighted magnetic resonance imaging, which was further confirmed by immunohistochemistry. Therefore, oxaliplatin-Au-Fe 3 O 4 -Herceptin is a promising multifunctional platform for simultaneous magnetic traceable and HER2 targeted chemotherapy for gastric cancer.

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Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer

Cited by 47 publications

References 55 publications

Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Biological impact of superparamagnetic iron oxide nanoparticles for magnetic particle imaging of head and neck cancer cells

Target‑specific delivery of oxaliplatin to HER2‑positive gastric cancer cells inï¿½vivo using oxaliplatin‑au‑fe3o4‑herceptin nanoparticles

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