1984
DOI: 10.1007/bf00766661
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Synthesis and biological activity of 7-amidinohydroxyalkyltheophyllines

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“…138 On refluxing in ethanol, the imidate 6a reacts with hydrochlorides of primary (168) or secondary (169) amines being thus converted into compounds 170 or 171. 139,140 2-Phenyliminopiperidine has been synthesised from the lactone 22a; first, the lactone was converted into the imidate 6a by treatment with dimethyl sulfoxide, and then the latter was made to condense with aniline. A large number of analogous aryliminopiperidines 172 were prepared directly from the lactone 22a by its condensation with arylamines in the presence of POCl 3 .…”
Section: Reactions With Amines and Their Derivativesmentioning
confidence: 99%
“…138 On refluxing in ethanol, the imidate 6a reacts with hydrochlorides of primary (168) or secondary (169) amines being thus converted into compounds 170 or 171. 139,140 2-Phenyliminopiperidine has been synthesised from the lactone 22a; first, the lactone was converted into the imidate 6a by treatment with dimethyl sulfoxide, and then the latter was made to condense with aniline. A large number of analogous aryliminopiperidines 172 were prepared directly from the lactone 22a by its condensation with arylamines in the presence of POCl 3 .…”
Section: Reactions With Amines and Their Derivativesmentioning
confidence: 99%