Synthesis and biological activity of mono- and tricyclic derivatives of 2-amino-3-cyanopyridine

A Facile Synthesis of 5‐Phenyl‐Dibenzo[b, g][1,8]Napthyridines

“…Literature cites that 3‐formyl‐4‐( N ‐phenylamino) pyridines underwent cyclization easily in the presence of POCl 3 to give naphthyridines; here, the formyl group was located at the ortho position to the aryl amino group on the pyridine ring.…”

Synthesis and functionalization of 4-arylamino-2-pyridone derivatives

“…1, 9 5 Formylpyridines can be used to synthesize compounds containing electron releasing substituted amino groups and two electron withdrawing cyano groups. 1, 9 5 Formylpyridines can be used to synthesize compounds containing electron releasing substituted amino groups and two electron withdrawing cyano groups.…”

Pyridopyridines

“…65 When heated with POCl 3 , substituted pyridone 76 underwent cyclisation with simultaneous replacement of the 2-oxo group by the chlorine atom to give 3-chloro-4-cyanobenzo[b] [1,6]naphthyridine 77. 66,67 The reaction of pyridone 78 with carbon disulfide and sodium hydride in benzene followed by methylation with iodomethane produced the 5,7-bis(methylthio)-1,6-naphthyridinone derivative 79. 68 5,6,7,8-Tetrahydro-1,6-naphthyridin-5-ones 80 were synthesised by the reactions of 4-amino-5,6-dihydropyridin-2(1H)-one with amino ketone hydrochlorides.…”