Synthesis and Biological Evaluation of 7‐N‐(n‐Alkoxyphthalimido)‐2‐hydroxy‐4‐aryl‐6‐aryliminothiazolidino [2,3‐b]pyrimidines and Related Compounds.

Abstract

Synthesis and Biological Evaluation of 7-N-(n-Alkoxyphthalimido)-2-hydroxy--4-aryl-6-aryliminothiazolidino[2,3-b]pyrimidines and RelatedCompounds. -With a view to their potential biological activity different kinds of compounds such as (V) and (VII) are prepared. The structure-activity relationships are discussed. (VIIb) shows high activity against Staphylococcus aureus. -(SINGH, B. S.; MEHTA, D.; BAREGAMA, L. K.; TALESARA*, G. L.; Indian J.

One‐pot Synthesis of Bis[1‐N,7‐N‐diethoxyphthalimido‐4,4′‐{3,5‐dimethyl‐4‐(4‐N,N‐dimethyl Aminophenyl)‐4,7‐dihydro‐1H‐dipyrazolo[3,4‐b;4′,3′‐e]Pyridin‐8‐yl}‐phenyl] Compounds and Their Antiviral Evaluation Against Cytomegalovirus (CMV) and Varicella‐zoster Virus (VZV) in Human Embryonic Lung (HEL) Cells

“…These examples clearly demonstrate the remarkable potential of DHP derivatives as a source of valuable drug candidates. Various combinations of heterocyclic rings attached to alkoxyphthalimide group have been synthesized and tested for antimicrobial and antimalarial activities (Schemes and ).…”

Synthesis characterization and biological evaluation of some alkoxyphthalimide derivatives of 3-(4-substituted phenyl)-6,6-diphenyl-3,3a-dihydro-2H-imidazo[2,1-b]pyrazolo[3,4-d][1,3]thiazol-7(6H)-one

“…The ability to inhibit growth of malarial parasite Plasmodium falsiparum (Mamalis, 1971) have also been observed for several aminoxy derivatives. Heterocyclic rings attached to alkoxyphthalimide group have been synthesized (Banu et al, 2000) and tested for antimicrobial and antimalarial (Singh et al, 2004) activity. We planned to undertake the synthesis and characterization of some imidazole derivatives carrying the above biodynamic heterocyclic systems with the hope to achieve enhanced biological activity.…”

Synthesis and characterization of biologically significant 5,5′-(1,4-phenylene)bis(1-N-alkoxyphthalimido-3-aryl-2-pyrazoline) derivatives

“…Several derivatives of alkoxyphthalimide have been synthesized [18,19] and reported to demonstrate a wide range of pharmacological activities i.e. anticancer [20], antimalarial [21], anticonvulsant [22] etc. In view of these observation and in continuation of our work on pyrazoline based heterocycles, it was considered to synthesize new chemical entities incorporating the two active pharmacophores namely, pyrazoline and alkoxyphthalimide in a single molecular framework using chalcones of teraphthaldehyde and substituted acetophenones as basic building blocks.…”