Synthesis and biological in vitro evaluation of the effect of hydroxyimino steroidal derivatives on breast cancer cells

Carrasco-Carballo, Alan; Hernández-Linares, María Guadalupe; Cárdenas-García, Maura; Sandoval‐Ramírez, Jesús

doi:10.1016/j.steroids.2020.108787

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…Carballo et al designed and synthesized a series of novel hydroxyimino steroidal derivatives and evaluated their antiproliferative activity in MCF7 and MDA-MB-231 breast cancer cells [ 80 ]. Compounds 5d – 5e ( Figure 8 ) were able to decrease cell proliferation with IC 50 values ranging from 9.3 to 11.8 µM ( Table 7 ).…”

Section: Steroidal Oximes As Antitumor Agentsmentioning

confidence: 99%

The Structural Diversity and Biological Activity of Steroid Oximes

et al. 2023

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Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N−OH and they exist as colorless crystals and are poorly soluble in water. Oximes can be easily obtained through the condensation of aldehydes or ketones with various amine derivatives, making them a very interesting chemical group in medicinal chemistry for the design of drugs as potential treatments for several diseases. In this review, we will focus on the different biological activities displayed by steroidal oximes such as anticancer, anti-inflammatory, antibacterial, antifungal and antiviral, among others, as well as their respective mechanisms of action. An overview of the chemistry of oximes will also be reported, and several steroidal oximes that are in clinical trials or already used as drugs are described. An extensive literature search was performed on three main databases—PubMed, Web of Science, and Google Scholar.

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Section: Steroidal Oximes As Antitumor Agentsmentioning

confidence: 99%

The Structural Diversity and Biological Activity of Steroid Oximes

et al. 2023

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“…According to the Global Cancer Observatory, breast cancer is a prevalent malignancy in women and is the leading cause of cancer‐related deaths among them 1–3 . Despite advances in breast cancer diagnosis and treatment, the disease remains a challenge for global research 4 .…”

Section: Introductionmentioning

confidence: 99%

“…According to the Global Cancer Observatory, breast cancer is a prevalent malignancy in women and is the leading cause of cancer‐related deaths among them. 1 , 2 , 3 Despite advances in breast cancer diagnosis and treatment, the disease remains a challenge for global research. 4 Therefore, it is necessary to identify novel biomarkers and molecular mechanisms in BC to enable early diagnosis and therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

In silico identification and in vitro evaluation of MRPS30‐DT lncRNA and MRPS30 gene expression in breast cancer

Shirani,

Mahdi‐Esferizi,

Eshraghi Samani

et al. 2024

Cancer Reports

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BackgroundIt has been reported that long non‐coding RNAs (lncRNAs) can play important roles in a variety of biological processes and cancer regulatory networks, including breast cancer.AimsThis study aimed to identify a novel upregulated lncRNA in breast cancer and its associated gene using bioinformatics analysis, and then evaluate their potential roles in breast cancer.Methods and ResultsExtensive in silico studies were performed using various bioinformatics databases and tools to identify a potential upregulated breast cancer‐associated lncRNA and its co‐expressed gene, and to predict their potential roles, functions, and interactions. The expression level of MRPS30‐DT lncRNA and MRPS30 was assessed in both BC tissues and cell lines using qRT‐PCR technology. MRPS30‐DT lncRNA and MRPS30 were selected as target genes using bioinformatics analysis. We found that MRPS30‐DT and MRPS30 were significantly overexpressed in BC tissues compared with normal tissues. Also, MRPS30 showed upregulation in all three BC cell lines compared with HDF. On the other hand, MRPS30‐DT significantly increased in MDA‐MB‐231 compared with HDF. While the expression of MRPS30‐DT was significantly dropped in the resistance cell line MCF/MX compared to HDF and MCF7. Moreover, bioinformatics analysis suggested that MRPS30‐DT and MRPS30 may play a potential role in BC through their involvement in some cancer signaling pathways and processes, as well as through their interaction with TFs, genes, miRNAs, and proteins related to carcinogenesis.ConclusionsOverall, our findings showed the dysregulation of MRPS30‐DT lncRNA and MRPS30 may provide clues for exploring new therapeutic targets or molecular biomarkers in BC.

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“…Studies over the past six decades have helped to develop different therapy treatments, such as surgery, radiotherapy, immunotherapy, photodynamic therapy, chemotherapy, monoclonal antibodies, and combination chemotherapy. Chemotherapy is based on small molecules that can act as inhibitors [2,3], antioxidants [4][5][6][7], and apoptosis-inducing agents drugs [2,8,9]. One of the main drawbacks of this therapy is that these anticancer agents target both cancer cells and normal host cells [3].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity

Arrieche,

Olea,

Jara-Gutiérrez

et al. 2024

Plants

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Pintoa chilensis is a shrub with yellow flowers that reach up to two meters high, endemic of the Atacama Region in Chile. This species grows under special environmental conditions such as low altitude, arid areas, and directly sun-exposed habitats. In the present study, ethanolic extract was obtained from fruits of P. chilensis, and then partitioned in solvents of increasing polarity to obtain five fractions: hexane (HF), dichloromethane (DF), ethyl acetate (AF), and the residual water fraction (QF). The antioxidant activity of extracts was evaluated by using the DPPH, ABTS, and FRAP methods. The results show that the antioxidant capacity of P. chilensis is higher than that reported for other plants growing in similar environments. This effect is attributed to the highest content of flavonoids and total phenols found in P. chilensis. On the other hand, the cell viability of a breast cancer cell line (MCF-7) and a non-tumor cell line (MCF-10A) was assessed in the presence of different extract fractions. The results indicate that the hexane fraction (HF) exhibits the highest cytotoxicity on both cell lines (IC50 values equal to 35 and 45 µg/mL), whereas the dichloromethane fraction (DF) is the most selective one. The GC–MS analysis of the dichloromethane fraction (DF) shows the presence of fatty acids, sugars, and polyols as major components.

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Synthesis and biological in vitro evaluation of the effect of hydroxyimino steroidal derivatives on breast cancer cells

Cited by 8 publications

References 56 publications

The Structural Diversity and Biological Activity of Steroid Oximes

The Structural Diversity and Biological Activity of Steroid Oximes

In silico identification and in vitro evaluation of MRPS30‐DT lncRNA and MRPS30 gene expression in breast cancer

Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity

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